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https://hdl.handle.net/11147/15413
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tang, William W. | - |
dc.contributor.author | Battistone, Ben | - |
dc.contributor.author | Bauer, Kaylyn M. | - |
dc.contributor.author | Weis, Allison M. | - |
dc.contributor.author | Barba, Cindy | - |
dc.contributor.author | Fadlullah, Muhammad Zaki Hidayatullah | - |
dc.contributor.author | O'Connell, Ryan M. | - |
dc.date.accessioned | 2025-02-25T20:01:13Z | - |
dc.date.available | 2025-02-25T20:01:13Z | - |
dc.date.issued | 2025 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | https://doi.org/10.1016/j.celrep.2025.115301 | - |
dc.description | Weis, Allison/0000-0001-9991-1661; Tantalla, Jacob/0000-0002-9565-4888 | en_US |
dc.description.abstract | The rising incidence of advanced-stage colorectal cancer (CRC) and poor survival outcomes necessitate new and effective therapies. Immune checkpoint inhibitors (ICIs), specifically anti-PD-1 therapy, show promise, yet clinical determinants of a positive response are suboptimal. Here, we identify microRNA-155 (miR-155) as necessary for CD8+ T cell-infiltrated tumors through an unbiased in vivo CRISPR-Cas9 screen identifying functional tumor antigen-specific CD8+ T cell-expressed microRNAs. T cell miR-155 is required for anti-PD-1 responses and for a vital intratumor CD8+ T cell differentiation cascade by repressing Ship-1, inhibiting Tcf-1 and stemness, and subsequently enhancing Cxcr6 expression, anti-tumor immunity, and effector functions. Based on an underlying miR-155-dependent CD8+ T cell transcriptional profile, we identify a gene signature that predicts ICI responses across 12 diverse cancers. Together, our findings support a model whereby miR155 serves as a central regulator of CD8+ T cell-dependent cancer immunity and ICI responses that may be leveraged for future therapeutics. | en_US |
dc.description.sponsorship | NIH [5R01AG079477, 5F30CA260977] | en_US |
dc.description.sponsorship | We would like to thank the following University of Utah Core Facilities: the HCI-High-Throughput Genomics and Bioinformatics Resources for performing scRNA-seq, the HSC Flow Cytometry Core Facility for cell sorting, and the DNA/Peptide Synthesis Core for primer synthesis. W.W.T. was funded by NIH grant 5F30CA260977, and R.M.O. was funded by NIH grant 5R01AG079477. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Cell Press | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.title | A Microrna-Regulated Transcriptional State Defines Intratumoral Cd8+t Cells That Respond To Immunotherapy | en_US |
dc.type | Article | en_US |
dc.authorid | Weis, Allison/0000-0001-9991-1661 | - |
dc.authorid | Tantalla, Jacob/0000-0002-9565-4888 | - |
dc.department | İzmir Institute of Technology | en_US |
dc.identifier.volume | 44 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.wos | WOS:001427429900001 | - |
dc.identifier.scopus | 2-s2.0-85217423011 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.celrep.2025.115301 | - |
dc.identifier.pmid | 39951377 | - |
dc.authorwosid | Stephen Victor, Emmanuel/Hdn-0252-2022 | - |
dc.authorwosid | Tan, Aik Choon/A-3135-2011 | - |
dc.authorwosid | Fadlullah Wilmot, Muhammad Zaki/Iyj-5784-2023 | - |
dc.authorwosid | Ekiz, Huseyin/Aek-2662-2022 | - |
dc.authorwosid | Weis, Allison/O-8184-2016 | - |
dc.identifier.wosquality | Q1 | - |
dc.identifier.scopusquality | Q1 | - |
dc.description.woscitationindex | Science Citation Index Expanded | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Article | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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