Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/15413
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dc.contributor.authorTang, William W.-
dc.contributor.authorBattistone, Ben-
dc.contributor.authorBauer, Kaylyn M.-
dc.contributor.authorWeis, Allison M.-
dc.contributor.authorBarba, Cindy-
dc.contributor.authorFadlullah, Muhammad Zaki Hidayatullah-
dc.contributor.authorO'Connell, Ryan M.-
dc.date.accessioned2025-02-25T20:01:13Z-
dc.date.available2025-02-25T20:01:13Z-
dc.date.issued2025-
dc.identifier.issn2211-1247-
dc.identifier.urihttps://doi.org/10.1016/j.celrep.2025.115301-
dc.descriptionWeis, Allison/0000-0001-9991-1661; Tantalla, Jacob/0000-0002-9565-4888en_US
dc.description.abstractThe rising incidence of advanced-stage colorectal cancer (CRC) and poor survival outcomes necessitate new and effective therapies. Immune checkpoint inhibitors (ICIs), specifically anti-PD-1 therapy, show promise, yet clinical determinants of a positive response are suboptimal. Here, we identify microRNA-155 (miR-155) as necessary for CD8+ T cell-infiltrated tumors through an unbiased in vivo CRISPR-Cas9 screen identifying functional tumor antigen-specific CD8+ T cell-expressed microRNAs. T cell miR-155 is required for anti-PD-1 responses and for a vital intratumor CD8+ T cell differentiation cascade by repressing Ship-1, inhibiting Tcf-1 and stemness, and subsequently enhancing Cxcr6 expression, anti-tumor immunity, and effector functions. Based on an underlying miR-155-dependent CD8+ T cell transcriptional profile, we identify a gene signature that predicts ICI responses across 12 diverse cancers. Together, our findings support a model whereby miR155 serves as a central regulator of CD8+ T cell-dependent cancer immunity and ICI responses that may be leveraged for future therapeutics.en_US
dc.description.sponsorshipNIH [5R01AG079477, 5F30CA260977]en_US
dc.description.sponsorshipWe would like to thank the following University of Utah Core Facilities: the HCI-High-Throughput Genomics and Bioinformatics Resources for performing scRNA-seq, the HSC Flow Cytometry Core Facility for cell sorting, and the DNA/Peptide Synthesis Core for primer synthesis. W.W.T. was funded by NIH grant 5F30CA260977, and R.M.O. was funded by NIH grant 5R01AG079477.en_US
dc.language.isoenen_US
dc.publisherCell Pressen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleA Microrna-Regulated Transcriptional State Defines Intratumoral Cd8+t Cells That Respond To Immunotherapyen_US
dc.typeArticleen_US
dc.authoridWeis, Allison/0000-0001-9991-1661-
dc.authoridTantalla, Jacob/0000-0002-9565-4888-
dc.departmentİzmir Institute of Technologyen_US
dc.identifier.volume44en_US
dc.identifier.issue2en_US
dc.identifier.wosWOS:001427429900001-
dc.identifier.scopus2-s2.0-85217423011-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.celrep.2025.115301-
dc.identifier.pmid39951377-
dc.authorwosidStephen Victor, Emmanuel/Hdn-0252-2022-
dc.authorwosidTan, Aik Choon/A-3135-2011-
dc.authorwosidFadlullah Wilmot, Muhammad Zaki/Iyj-5784-2023-
dc.authorwosidEkiz, Huseyin/Aek-2662-2022-
dc.authorwosidWeis, Allison/O-8184-2016-
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ1-
dc.description.woscitationindexScience Citation Index Expanded-
item.languageiso639-1en-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.cerifentitytypePublications-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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