Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/2087
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dc.contributor.authorMavi, Ayşe-
dc.contributor.authorÇermik, Tevfik F.-
dc.contributor.authorUrhan, Muammer-
dc.contributor.authorPüskülcü, Halis-
dc.contributor.authorBasu, Sandip-
dc.contributor.authorYu, Jian Q.-
dc.contributor.authorZhuang, Hongming-
dc.contributor.authorCzerniecki, Brian-
dc.contributor.authorAlavi, Abass-
dc.date.accessioned2016-08-11T12:13:06Z
dc.date.available2016-08-11T12:13:06Z
dc.date.issued2007-08
dc.identifier.citationMavi, A., Çermik, T. F., Urhan, M., Püskülcü, H., Basu, S., Yu, J. Q., Zhuang, H., Czerniecki, B., and Alavi, A. (2007). The effects of estrogen, progesterone, and C-erbB-2 receptor states on 18F-FDG uptake of primary breast cancer lesions. Journal of Nuclear Medicine, 48(8), 1266-1272. doi:10.2967/jnumed.106.037440en_US
dc.identifier.issn0161-5505
dc.identifier.issn0161-5505-
dc.identifier.urihttp://doi.org/10.2967/jnumed.106.037440
dc.identifier.urihttp://hdl.handle.net/11147/2087
dc.description.abstractThe purpose of this prospective study was to investigate whether correlations exist between 18F-FDG uptake of primary breast cancer lesions and predictive and prognostic factors such as estrogen receptor (ER), progesterone receptor (PR), and C-erbB-2 receptor (C-erbB-2R) states. Methods: Before undergoing partial or total mastectomy, 213 patients with newly diagnosed breast cancer underwent 18F-FDG PET (5.2 MBq/kg of body weight). The maximum standardized uptake value (SUV) of the primary lesion was measured in each patient. Standard immunohistochemistry was performed on a surgical specimen of the cancer lesion to characterize the receptor state of the tumor cells. Pearson χ2 tests were performed on the cross-tables of different receptor states to test any association that may exist among ER, PR, and C-erbB-2R. Maximum SUV measurements for different receptor states were compared using factorial ANOVA in a completely random design. Results: After exclusion of certain lesions, 118 lesions were analyzed for this study. The mean maximum SUVs of ER-positive and ER-negative lesions were 3.03 ± 0.26 and 5.64 ± 0.75, whereas those of PR were 3.24 ± 0.29 and 4.89 ± 0.67, respectively, and those of C-erbB-2R were 4.64 ± 0.70 and 3.70 ± 0.35, respectively, χ2 tests for ER and PR showed that if one is positive then the other tends to be positive as well (χ2 = 71.054, P < 0.01). For ER and C-erbB-2R states, if ER is positive, C-erbB-2R will more likely be negative (χ2 = 13.026, P < 0.01). No relationship was detected between PR and C-erbB-2R states (χ2 = 3.695, P > 0.05). ANOVAs showed that PR state alone (F = 0.095, P > 0.05) and C-erbB-2R state alone (F = 0.097, P > 0.05) had no effect on 18F-FDG uptake but ER state alone had an effect (F = 9.126, P < 0.01). ER and PR being together had no additional effect on 18F-FDG uptake. Our study also demonstrated that interactions exist between ER and C-erbB-2R state and between PR and C-erbB-2R state. Conclusion: SUV measurements may provide valuable information about the state of ER, PR, and C-erbB-2R and the associated glucose metabolism as measured by 18F-FDG uptake of the primary breast cancer lesions. Such an association may be of importance to treatment planning and outcome in these patients.en_US
dc.description.sponsorshipPublic Health Services research grant M01-RR00040en_US
dc.language.isoenen_US
dc.publisherSociety of Nuclear Medicine and Molecular Imagingen_US
dc.relation.ispartofJournal of Nuclear Medicineen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBreast canceren_US
dc.subjectEstrogenen_US
dc.subjectInteractions between receptorsen_US
dc.subjectProgesteroneen_US
dc.subjectCorrelation analysisen_US
dc.titleThe effects of estrogen, progesterone, and C-erbB-2 receptor states on 18F-FDG uptake of primary breast cancer lesionsen_US
dc.typeArticleen_US
dc.institutionauthorPüskülcü, Halis-
dc.departmentIzmir Institute of Technology. Computer Engineeringen_US
dc.identifier.volume48en_US
dc.identifier.issue8en_US
dc.identifier.startpage1266en_US
dc.identifier.endpage1272en_US
dc.identifier.wosWOS:000248584300023en_US
dc.identifier.scopus2-s2.0-34547773618en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.2967/jnumed.106.037440-
dc.identifier.pmid17631558en_US
dc.relation.doi10.2967/jnumed.106.037440en_US
dc.coverage.doi10.2967/jnumed.106.037440en_US
local.message.claim2022-06-06T14:28:42.078+0300|||rp02964|||submit_approve|||dc_contributor_author|||None*
dc.identifier.scopusqualityQ1-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.dept03.04. Department of Computer Engineering-
Appears in Collections:Computer Engineering / Bilgisayar Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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