Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/2359
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dc.contributor.authorUral, Ali Uğur-
dc.contributor.authorAvcu, Ferit-
dc.contributor.authorBaran, Yusuf-
dc.date.accessioned2016-11-01T11:17:53Z-
dc.date.available2016-11-01T11:17:53Z-
dc.date.issued2008-09-
dc.identifier.citationUral, A. U., Avcu, F., and Baran, Y. (2008). Bisphosphonate treatment and radiotherapy in metastatic breast cancer. Medical Oncology, 25(3), 350-355. doi:10.1007/s12032-008-9044-4en_US
dc.identifier.issn1357-0560-
dc.identifier.issn1559-131X-
dc.identifier.urihttp://doi.org/10.1007/s12032-008-9044-4-
dc.identifier.urihttp://hdl.handle.net/11147/2359-
dc.description.abstractPatients with advanced breast cancer frequently develop metastasis to bone. Bone metastasis results in intractable pain and high risk of pathologic fractures due to osteolysis. The treatment of breast cancer patients with bone metastases requires a multidisciplinary approach. Radiotherapy is an established treatment for metastatic bone pain. It may be delivered either as a localized low dose treatment for localized bone pain or systemically for more widespread symptoms. Bisphosphonates have been shown to reduce morbidity and bone pain from bone metastases when given to patients with metastatic bone disease. In vivo studies indicate that early bisphosphonates administration in combination with radiotherapy improves remineralization and restabilization of osteolytic bone metastases in animal tumor models. This review focused on a brief discussion about biology of bone metastases, the effects of radiotherapy and bisphosphonate therapy, and possible mechanisms of combination therapy in metastatic breast cancer patients.en_US
dc.language.isoenen_US
dc.publisherHumana Pressen_US
dc.relation.ispartofMedical Oncologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBisphosphonatesen_US
dc.subjectBreast canceren_US
dc.subjectCombination therapyen_US
dc.subjectRadiotherapyen_US
dc.titleBisphosphonate treatment and radiotherapy in metastatic breast canceren_US
dc.typeArticleen_US
dc.institutionauthorBaran, Yusuf-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume25en_US
dc.identifier.issue3en_US
dc.identifier.startpage350en_US
dc.identifier.endpage355en_US
dc.identifier.wosWOS:000260250400017en_US
dc.identifier.scopus2-s2.0-58149252810en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s12032-008-9044-4-
dc.identifier.pmid18202925en_US
dc.relation.doi10.1007/s12032-008-9044-4en_US
dc.coverage.doi10.1007/s12032-008-9044-4en_US
dc.identifier.wosqualityQ4-
dc.identifier.scopusqualityQ2-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.openairetypeArticle-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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