Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/2609
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dc.contributor.authorAkgül, Bünyamin-
dc.contributor.authorLin, Kai-Wei-
dc.contributor.authorYang, Hui-Mei Ou-
dc.contributor.authorChen, Yen-Hui-
dc.contributor.authorLu, Tzu-Huan-
dc.contributor.authorChen, Chien-Hsiun-
dc.contributor.authorKikuchi, Tateki-
dc.contributor.authorChen, Yuan-Tsong-
dc.contributor.authorTu, Chen-Pei D.-
dc.date.accessioned2016-12-13T07:31:56Z-
dc.date.available2016-12-13T07:31:56Z-
dc.date.issued2010-
dc.identifier.citationAkgül, B., Lin, K.-W., Yang, H.-M. O., Chen, Y.-H., Lu, T.-H., Chen, C.-H., Kikuchi, T., Chen, Y.-T., and Tu, C.-P. D. (2010). Garlic accelerates red blood cell turnover and splenic erythropoietic gene expression in mice: Evidence for erythropoietin-independent erythropoiesis. PLoS ONE, 5(12). doi:10.1371/journal.pone.0015358en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://doi.org/10.1371/journal.pone.0015358-
dc.identifier.urihttp://hdl.handle.net/11147/2609-
dc.description.abstractGarlic (Allium sativum) has been valued in many cultures both for its health effects and as a culinary flavor enhancer. Garlic's chemical complexity is widely thought to be the source of its many health benefits, which include, but are not limited to, anti-platelet, procirculatory, anti-inflammatory, anti-apoptotic, neuro-protective, and anti-cancer effects. While a growing body of scientific evidence strongly upholds the herb's broad and potent capacity to influence health, the common mechanisms underlying these diverse effects remain disjointed and relatively poorly understood. We adopted a phenotypedriven approach to investigate the effects of garlic in a mouse model. We examined RBC indices and morphologies, spleen histochemistry, RBC half-lives and gene expression profiles, followed up by qPCR and immunoblot validation. The RBCs of garlic-fed mice register shorter half-lives than the control. But they have normal blood chemistry and RBC indices. Their spleens manifest increased heme oxygenase 1, higher levels of iron and bilirubin, and presumably higher CO, a pleiotropic gasotransmitter. Heat shock genes and those critical for erythropoiesis are elevated in spleens but not in bone marrow. The garlic-fed mice have lower plasma erythropoietin than the controls, however. Chronic exposure to CO of mice on garlic-free diet was sufficient to cause increased RBC indices but again with a lower plasma erythropoietin level than air-treated controls. Furthermore, dietary garlic supplementation and CO treatment showed additive effects on reducing plasma erythropoietin levels in mice. Thus, garlic consumption not only causes increased energy demand from the faster RBC turnover but also increases the production of CO, which in turn stimulates splenic erythropoiesis by an erythropoietinindependent mechanism, thus completing the sequence of feedback regulation for RBC metabolism. Being a pleiotropic gasotransmitter, CO may be a second messenger for garlic's other physiological effects.en_US
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS ONEen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAllium sativumen_US
dc.subjectGarlicen_US
dc.subjectScanning electron microscopyen_US
dc.subjectAnimal cellen_US
dc.subjectRNAen_US
dc.subjectTranscription factor GATA 1en_US
dc.titleGarlic accelerates red blood cell turnover and splenic erythropoietic gene expression in mice: Evidence for erythropoietin-independent erythropoiesisen_US
dc.typeArticleen_US
dc.authoridTR37475en_US
dc.institutionauthorAkgül, Bünyamin-
dc.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume5en_US
dc.identifier.issue12en_US
dc.identifier.wosWOS:000285793200025en_US
dc.identifier.scopus2-s2.0-78650837101en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1371/journal.pone.0015358-
dc.identifier.pmid21206920en_US
dc.relation.doi10.1371/journal.pone.0015358en_US
dc.coverage.doi10.1371/journal.pone.0015358en_US
dc.identifier.scopusqualityQ1-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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