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Title: Relative protein quantitation with post translational modifications in mass spectrometry based proteomics
Authors: Allmer, Jens
Keywords: Proteins
Chromatographic analysis
Mass spectrometry
Molecular biology
Issue Date: 2010
Publisher: Institute of Electrical and Electronics Engineers Inc.
Source: Allmer, J. (2010). Relative protein quantitation with post translational modifications in mass spectrometry based proteomics. Paper presented at the 5th International Symposium on Health Informatics and Bioinformatics. doi:10.1109/HIBIT.2010.5478886
Abstract: Mass spectrometry has become the tool of choice for most investigations in proteomics. Identification of proteins from complex mixtures has long been achieved and is now routinely used in countless high throughput studies. Quantitation by mass spectrometry is comparably newer and many different strategies have been proposed. One such strategy quantitates the difference in protein expression level among samples via extracted ion chromatograms, or spectral counts or a combination thereof. Another strategy involves mass modifications of the analytes in one or more of the samples under investigation. MSMAG has been developed as an extension to 2DB and it has been shown that it can aid in quantitation of data from experiments employing label-free quantitation. Recently, it has been extended to allow for analysis of data based on labelling strategies. This also makes it possible to quickly visualize and investigate inherent mass differences as presented by post translational modifications. ©2009 IEEE.
Description: 5th International Symposium on Health Informatics and Bioinformatics, HIBIT 2010; Antalya; Turkey; 20 April 2010 through 22 April 2010
ISBN: 9781424459704
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

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