Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/2726
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dc.contributor.authorBaran, Yusuf-
dc.contributor.authorÖztekin, Coşkun-
dc.contributor.authorBaşsoy, Esen Yonca-
dc.date.accessioned2017-01-05T12:36:30Z-
dc.date.available2017-01-05T12:36:30Z-
dc.date.issued2010-06-
dc.identifier.citationBaran, Y., Öztekin, C., and Başsoy, E. Y. (2010). Combination of fludarabine and imatinib induces apoptosis synergistically through loss of mitochondrial membrane potential and increases in caspase-3 enzyme activity in human K562 chronic myleloid leukemia cells. Cancer Investigation, 28(6), 623-628. doi:10.3109/07357901003631056en_US
dc.identifier.issn0735-7907-
dc.identifier.urihttp://doi.org/10.3109/07357901003631056-
dc.identifier.urihttp://hdl.handle.net/11147/2726-
dc.description.abstractIn this study, we aimed to show the synergistic apoptotic effects of imatinib/fludarabine combination in human K562 chronic myleloid leukemia (CML) cells. There was a significant increase in cytotoxicity of combination of imatinib and fludarabine as compared to any agent alone. On the other hand, combination of both agents induced apoptosis significantly as confirmed by increases in caspase-3 enzyme activity and decreases in mitochondrial membrane potential. As a summary, the results of this study strongly suggest that combination of imatinib and fludarabine induced cell death synergistically comparing to only imatinib or fludarabine in human K562 CML cells. Copyright © 2010 Informa Healthcare USA, Inc.en_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofCancer Investigationen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectBCR/ABLen_US
dc.subjectChronic myeloid leukemiaen_US
dc.subjectFludarabineen_US
dc.subjectImatiniben_US
dc.titleCombination of fludarabine and imatinib induces apoptosis synergistically through loss of mitochondrial membrane potential and increases in caspase-3 enzyme activity in human K562 chronic myleloid leukemia cellsen_US
dc.typeArticleen_US
dc.authoridTR119193en_US
dc.institutionauthorBaran, Yusuf-
dc.institutionauthorBaşsoy, Esen Yonca-
dc.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume28en_US
dc.identifier.issue6en_US
dc.identifier.startpage623en_US
dc.identifier.endpage628en_US
dc.identifier.wosWOS:000278740000006en_US
dc.identifier.scopus2-s2.0-77953182889en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.3109/07357901003631056-
dc.identifier.pmid20307198en_US
dc.relation.doi10.3109/07357901003631056en_US
dc.coverage.doi10.3109/07357901003631056en_US
dc.identifier.scopusqualityQ1-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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