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Title: Protective effect of seleno-L-methionine on cyclophosphamide-induced urinary bladder toxicity in rats
Authors: Ayhancı, Adnan
Yaman, Suzan
Şahintürk, Varol
Uyar, Ruhi
Bayramoğlu, Gökhan
Şentürk, Hakan
Altuner, Yılmaz
Appak, Sıla
Güneş, Sibel
Keywords: Cyclophosphamide
Issue Date: Apr-2010
Publisher: Humana Press
Source: Ayhancı, A., Yaman, S., Şahintürk, V., Uyar, R., Bayramoğlu, G., Şentürk, H., Altuner, Y., Appak, S., and Güneş, S. (2010). Protective effect of seleno-L-methionine on cyclophosphamide-induced urinary bladder toxicity in rats. Biological Trace Element Research, 134(1), 98-108. doi:10.1007/s12011-009-8458-y
Abstract: Cyclophosphamide (CP) is a widely used antineoplastic drug, which could cause toxicity of the normal cells due to its toxic metabolites. Its urotoxicity may cause dose-limiting side effects like hemorrhagic cystitis. Overproduction of reactive oxygen species (ROS) during inflammation is one of the reasons of the urothelial injury. Selenoproteins play crucial roles in regulating ROS and redox status in nearly all tissues; therefore, in this study, the urotoxicity of CP and the possible protective effects of seleno-l-methionine (SLM) on urinary bladder of rats were investigated. Intraperitoneal (i.p.) administration of 50, 100, or 150 mg/kg CP induced cystitis, in a dose-dependent manner, as manifested by marked congestion, edema and extravasation in rat urinary bladder, a marked desquamative damage to the urothelium, severe inflammation in the lamina propria, focal erosions, and polymorphonuclear (PMN) leukocytes associated with occasional lymphocyte infiltration determined by macroscopic and histopathological examination. In rat urinary bladder tissue, a significant decrease in the endogenous antioxidant compound glutathione, and elevation of lipid peroxidation were also noted. Pretreatment with SLM (0.5 or 1 mg/kg) produced a significant decrease in the bladder edema and caused a marked decrease in vascular congestion and hemorrhage and a profound improvement in the histological structure. Moreover, SLM pretreatment decreased lipid peroxide significantly in urinary bladder tissue, and glutathione content was greatly restored. These results suggest that SLM offers protective effects against CP-induced urinary bladder toxicity and could be used as a protective agent against the drug toxicity. © 2009 Humana Press Inc.
ISSN: 0163-4984
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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