Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.advisorTıhmınlıoğlu, Fundaen
dc.contributor.authorAltıok, Duygu-
dc.descriptionThesis (Doctoral)--Izmir Institute of Technology, Chemical Engineering, Izmir, 2011en
dc.descriptionIncludes bibliographical references (leaves: 110-127)en
dc.descriptionText in English; Abstract: Turkish and Englishen
dc.descriptionxiii, 149 leavesen
dc.descriptionFull text release delayed at author's request until 2014.08.24-
dc.description.abstractThe main focus of this dissertation is to develop chitosan based microspheres loaded with antibiotic and essential oil to eradicate Helicobacter pylori by maintaining the constant drug level and prolonged gastric retention. The primary objective was to show that novel essential oil loaded microspheres are promising in the treatment of H. pylori infection as an alternative to conventional antibiotic therapy. In this context, firstly, the minimum inhibitory concentration of clarithromycin and five essential oils namely lemongrass oil, thyme oil, clove leaf oil, lemon oil and cinnamon bark oil on H. pylori was investigated. Among five essential oils, cinnamon bark oil showed the strongest anti-H. pylori activity. After choosing the most effective essential oil on H. pylori, we focused on the preparation of clarithromycin and cinnamon bark oil loaded microspheres by spray drying technique. Spray drying conditions were optimized by reponse surface methodology. Genipin, a natural crosslinker, was used as a crosslinking agent to achieve controlled drug release. Finally, it was aimed to investigate the clarithromycin and essential oil release in buffer solution and their antibacterial activity on H. pylori when released from microspheres. Higuchi equation well described the release characteristics. Drug release from microspheres was diffusion controlled. Cinnamon bark oil and clarithromycin released from the microspheres inhibited the growth of H. pylori resulting that the antibacterial activity of cinnamon bark oil and clarithromycin was maintained during the microsphere manufacturing. In conclusion, clarithromycin and cinnamon bark oil loaded chitosan microspheres have a great potential to be used as a control release system in treatment of H. pylori infection.en
dc.publisherIzmir Institute of Technologyen
dc.subject.lcshHelicobacter pylori infectionsen
dc.titlePreparation and evaluation of chitosan microspheres for eradication of helicobacter pylorien_US
dc.typeDoctoral Thesisen_US
dc.departmentThesis (Doctoral)--İzmir Institute of Technology, Chemical Engineeringen_US
item.fulltextWith Fulltext-
item.openairetypeDoctoral Thesis-
Appears in Collections:Phd Degree / Doktora
Files in This Item:
File Description SizeFormat 
412042.pdfDoctoralThesis4.04 MBAdobe PDFThumbnail
Show simple item record

CORE Recommender

Page view(s)

checked on Nov 27, 2023


checked on Nov 27, 2023

Google ScholarTM


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.