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Title: Analysis of temporal and spatial expression of drosophila embryonic small RNAs by deep-sequencing method
Authors: Akgül, Bünyamin
Coşacak, Mehmet İlyas
Issue Date: 2012
Publisher: Izmir Institute of Technology
Abstract: The world of small RNAs is expanding and new types of small RNAs are being identified. By using deep-sequencing techniques in addition to most abundant small RNAs; miRNA and siRNA, piRNA and tRFs were further characterized and shown to be functional. The global behavior of small RNAs during MZT and their location in the cytoplasmic complexes has not been shown. By combining polysomal fractionation and deep-sequencing technique as well as the highly regulated developmental stages in Drosophila we have shown that the temporal and spatial expression of small RNAs changes during MZT. We have shown that each small RNA group has unique behaviour in cytoplasm and is enriched in specific polysomal fractions which shows that their local function in cytoplasmic complexes is mainly translational machinery.
Description: Thesis (Master)--Izmir Institute of Technology, Molecular Biology and Genetics, Izmir, 2012
Includes bibliographical references (leaves: 37-46)
Text in English; Abstract: Turkish and English
x, 46 leaves
Full text release delayed at author's request until 2015.08.01
Appears in Collections:Master Degree / Yüksek Lisans Tezleri

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