Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/3559
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dc.contributor.advisorAllmer, Jensen
dc.contributor.authorGültekin, Visam-
dc.date.accessioned2014-07-22T13:51:48Z-
dc.date.available2014-07-22T13:51:48Z-
dc.date.issued2012en
dc.identifier.urihttp://hdl.handle.net/11147/3559-
dc.descriptionThesis (Master)--Izmir Institute of Technology, Molecular Biology and Genetics, Izmir, 2012en
dc.descriptionIncludes bibliographical references (leaves: 47-54)en
dc.descriptionText in English; Abstract: Turkish and Englishen
dc.descriptionix, 54 leavesen
dc.descriptionFull text release delayed at author's request until 2016.01.29en
dc.description.abstractHigh-throughput next generation sequencing technologies progressed very rapidly; revolutionized genomics by providing a robust working field for new studies to be performed and promising the facilitation of the achievements that was extremely challenging before. Although the massive output of these instruments is getting more accurate, still delivers the projection of the real sequence in very short fragments; which necessitates another process of merging and ordering those fragments to reconstruct the larger sequences. This process is performed by sequence assemblers and in the absence of a reference genome; it becomes a de novo sequence assembly. Since assembling millions of fragments in biological aspects have many obvious challenges, there have been many studies specifically focused on developing tools that can adapt to newly announced sequencing technologies, take advantage of the computer science achievements and the technological advancement of computer hardware to the utmost. But these sequence assemblers also need to justify the gain they claim. We took 5 of the commonly used assemblers and assembled two genomic datasets, mined the never mentioned statistics before and commonly used statistics that thought to be the representative of the quality of the assembly. On top of that we also used experimentally validated data that is known to be a part of the organisms’ genome and trailed those in assemblies.en
dc.language.isoenen_US
dc.publisherIzmir Institute of Technologyen
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject.lcshGenetics--Techniqueen
dc.subject.lcshSequence alignment (Bioinformatics)en
dc.titleQuality assessment of de novo sequence assembly toolsen_US
dc.typeMaster Thesisen_US
dc.institutionauthorGültekin, Visam-
dc.departmentThesis (Master)--İzmir Institute of Technology, Molecular Biology and Geneticsen_US
dc.relation.publicationcategoryTezen_US
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairetypeMaster Thesis-
Appears in Collections:Master Degree / Yüksek Lisans Tezleri
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