Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.advisorAlsoy Altınkaya, Sacideen
dc.contributor.authorAbacı, Hasan Erbil-
dc.descriptionThesis (Master)--Izmir Institute of Technology, Chemical Engineering, Izmir, 2008en
dc.descriptionIncludes bibliographical references (leaves: 82-91)en
dc.descriptionText in English; Abstract: Turkish and Englishen
dc.descriptionxiii, 91 leavesen
dc.description.abstractRecent studies have shown that the effectiveness of hemodialysis is based on module geometry, membrane properties and operating conditions. Various experimental work exist in the literature concentrated on the synthesis of new hemodialysis membranes. However, optimization of membrane structure requires extensive and time consuming experimentations. Therefore, mathematical models are neccessary that can be used to predict the performance of hemodialysis operation. In this study, a predictive theoretical model was developed to predict the solute concentrations in patient.s blood and optimize the efficiency of hemodialysis operation. The model takes into account simultaneous mass and momentum transfer along with the adsorption of rejected protein molecules on the surface of the membrane.Model predictions show that blood and dialysate flowrates are effective for all sizes of molecules. The change in structural properties of the membrane makes no effect on the total removal of urea beacause of its high clearance. On the other hand, a considerable increment in the clearance of larger molecular weight solutes occurs as the pore size and porosity of the membrane increases. The most important design parameter for dialysis unit which influence the solute clearances significantly is found to be the effective diameter among the fibers in the dialyzer.The model is extended to investigate the use of urease immobilized membranes on the efficiency of the hemodialysis operation. The results have shown that urease immobilization enhances the removal of urea from the blood and decreases the protein adsorption capacity of the polysulfone membrane.Model predictions are compared with different sets of clearance data available in the literature. The agreement is found to be satisfactory which suggests that the model can be used as a tool to design or test the performance of dialysis units.en
dc.publisherIzmir Institute of Technologyen_US
dc.subject.lccRC901.7.E53 A116 2008en
dc.subject.lcshHemodialysis--Mathematical modelsen
dc.titleModeling of hemodialysis operationen_US
dc.typeMaster Thesisen_US
dc.institutionauthorAbacı, Hasan Erbil-
dc.departmentThesis (Master)--İzmir Institute of Technology, Chemical Engineeringen_US
item.fulltextWith Fulltext-
item.openairetypeMaster Thesis-
Appears in Collections:Master Degree / Yüksek Lisans Tezleri
Files in This Item:
File Description SizeFormat 
T000713.pdfMasterThesis894.16 kBAdobe PDFThumbnail
Show simple item record

CORE Recommender

Page view(s)

checked on May 22, 2023


checked on May 22, 2023

Google ScholarTM


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.