Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/3995
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dc.contributor.advisorAkgül, Bünyaminen
dc.contributor.authorTüncel, Özge-
dc.date.accessioned2014-07-22T13:52:54Z-
dc.date.available2014-07-22T13:52:54Z-
dc.date.issued2008en
dc.identifier.urihttp://hdl.handle.net/11147/3995-
dc.descriptionThesis (Master)--Izmir Institute of Technology, Molecular Biology and Genetics, Izmir, 2008en
dc.descriptionIncludes bibliographical references (leaves: 33-35)en
dc.descriptionText in English; Abstract: Turkish and Englishen
dc.descriptionx, 38 leavesen
dc.description.abstractAmong the small RNAs, microRNAs are a particular class of 21 to 23 nucleotide RNAs that negatively regulate translation and play a pivotal role in posttranscriptional gene expression. microRNAs are found in many phyla that control such diverse events as metabolism, cell fate, cell death and development.The aim of this study is to investigate molecular mechanism of miRNAmediated translational regulation by profiling developmentally important microRNAs according to their translational status and to identify new microRNAs that have roles in translational regulation during the embryogenesis of Drosophila. Following RNA purification from different embryonal stages the fractionated RNAs were analyzed by microRNA microarray. Preliminary results show that 9 miRNAs were expressed in both stages whereas 60 miRNAs were accumulated in RNA fractions of 8 hour embryos.Also there are 2 miRNAs in all fractions of both stages in Drosophila embryos. It can be concluded that most of them were expressed in late embryonal development and there does not appear to be a switch in microRNA profiles in fractions for different stages of embryos. The preliminary results suggest that microRNAs may suppress protein synthesis at pre-initiation and initiation phases based on the microarray data.Further studies are required to solidify the preliminary findings.en
dc.language.isoenen_US
dc.publisherIzmir Institute of Technologyen
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject.lccQH447. T626 2008en
dc.subject.lcshGenomicsen
dc.subject.lcshNon-coding RNAen
dc.subject.lcshDrosophila melanogaster--Embryologyen
dc.titleGenomic profiling of microRNAs regulating translation in drosophila melanogaster embryosen_US
dc.typeMaster Thesisen_US
dc.institutionauthorTüncel, Özge-
dc.departmentThesis (Master)--İzmir Institute of Technology, Molecular Biology and Geneticsen_US
dc.relation.publicationcategoryTezen_US
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeMaster Thesis-
item.languageiso639-1en-
item.fulltextWith Fulltext-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Master Degree / Yüksek Lisans Tezleri
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