Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/4302
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dc.contributor.advisorBayraktar, Oğuzen_US
dc.contributor.advisorBaşal Bayraktar, Güldemeten_US
dc.contributor.advisorAkhisaroğlu, Mustafaen_US
dc.contributor.authorUslu, Mehmet Emin-
dc.date.accessioned2015-05-20T10:33:43Z-
dc.date.available2015-05-20T10:33:43Z-
dc.date.issued2014-
dc.identifier.citationUslu, M. E. (2014). Investigation of hemostatic biomaterials containing plant extracts. Unpublished doctoral dissertation, İzmir Institute of Technology, İzmir, Turkeyen_US
dc.identifier.urihttp://hdl.handle.net/11147/4302-
dc.descriptionThesis (Doctoral)--İzmir Institute of Technology, Bioengineering, İzmir, 2014en_US
dc.descriptionFull text release delayed at author's request until 2018.01.20en_US
dc.descriptionIncludes bibliographical references (leaves: 67-71)en_US
dc.descriptionText in English; Abstract: Turkish and Englishen_US
dc.descriptionxi, 71 leavesen_US
dc.description.abstractHaemostasis in other words a process which causes bleeding to stop is very important in injury. Recent researches were focused on discovery of haemostatic agents and developing biomaterials which transfer them to the injury side. Therefore plant extracts and three dimensional biomaterials were widely investigated. In this research the extract of Equisetum arvense was investigated as a coagulatory agent. Silk fibroin-hyaluronic acid mixture was used for the preparation of three dimensional sponge like biomaterials. The prepared sponge forms could also be used as scaffold for wound healing. In this research effect of extraction parameters on extract composition and bioactivity was investigated. Effect of extraction parameters were analyzed on 6 factors at 3 levels. It was seen that extraction parameters had high influence on both composition and bioactivity of the prepared extract. Although it was reported that the extract of equisetum arvense had anticoagulant activity, in this research it was shown that changing parameters caused variation of extract bioactivity from anticoagulant to coagulant as a result of changing extract composition. Addition of extract into silk fibroin-hyaluronic acid mixture caused proteins to precipitate as a result of interaction between protein and phenolic compounds. As a result of this precipitation significant decrease in the mechanical strength of biomaterial was observed. In order to minimize this interaction, plant extract was added into the silk fibroin after mixing with hyaluronic acid solution. As a result, mechanical strength and pore size of the biomaterial were increased and pore distribution became more regular. Also biomaterial gained tubular network on both vertical and horizontal dimensions. This would help the proliferation and migration of the fibroblast cells and moreover prevent the formation of scar tissue.en_US
dc.language.isoenen_US
dc.publisherIzmir Institute of Technologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEquisetum arvenseen_US
dc.subjectHaemostasisen_US
dc.subjectBiomaterialsen_US
dc.titleInvestigation of hemostatic biomaterials containing plant extractsen_US
dc.title.alternativeBitki özütleri içeren hemostatik biyomalzemelerin araştırılmasıen_US
dc.typeDoctoral Thesisen_US
dc.departmentThesis (Doctoral)--İzmir Institute of Technology, Bioengineeringen_US
dc.relation.publicationcategoryTezen_US
item.openairetypeDoctoral Thesis-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
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