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dc.contributor.advisorPesen Okvur, Devrimen_US
dc.contributor.advisorÖzyüzer, Lütfien_US
dc.contributor.authorBatı, Gizem-
dc.identifier.citationBatı, G. (2014). Invadopodia formation on nanometer scale protein patterns. Unpublished master's thesis, İzmir Institute of Technology, İzmir, Turkeyen_US
dc.descriptionThesis (Master)--Izmir Institute of Technology, Biotechnology and Bioengineering, Izmir, 2014en_US
dc.descriptionFull text release delayed at author's request until 2018.01.26en_US
dc.descriptionIncludes bibliographical references (leaves: 104-109)en_US
dc.descriptionText in English; Abstract: Turkish and Englishen_US
dc.descriptionxvi, 109 leavesen_US
dc.description.abstractHow the positions of invadopodium in the cell are determined and if they have an adhesivefunction are not known. Using fluorescence microscopy and antibodies that recognize actin, cortactin and MT1-MMP proteins, invadopodia formed by breast cancer cells plated on protein nanopatterns of different geometeries and components after stimulation with epidermal growth factor which is known to induce invadopodia formation, were examined. Invadopodia formation was studied for the first time on nanometer scale, single and double active component, protein patterns with equal distance and gradient spacings. The results show that: • On K-casein-fibronectin nanopatterns, invadopodia prefer to form on K-casein which blocks cell adhesion rather than on fibronectin nanodots which promote cell adhesion. • On Laminin-fibronectin nanopatterns, invadopodia prefer to form on laminin rather than on fibronectin nanodots. • On gradient patterns, invadopodia prefer areas with wide spacings. These results support the hypotheses that the positions where invadopodia form can be determined by surface protein nanopatterns and that cell adhesion is not required at points where invadopodia will form.en_US
dc.publisherIzmir Institute of Technologyen_US
dc.subjectCancer cellsen_US
dc.subject.lcshCell adhesion--Molecular aspectsen_US
dc.titleInvadopodia formation on nanometer scale protein patternsen_US
dc.title.alternativeNanometre ölçeğindeki protein desenleri üzerinde işgalci-ayak oluşumuen_US
dc.typeMaster Thesisen_US
dc.institutionauthorBatı, Gizem-
dc.departmentIzmir Institute of Technology. Biotechnology and Bioengineeringen_US
item.openairetypeMaster Thesis-
item.fulltextWith Fulltext-
Appears in Collections:Master Degree / Yüksek Lisans Tezleri
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