Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.advisorÇağır, Alien_US
dc.contributor.authorAkçok, İsmail-
dc.identifier.citationAkçok, İ. (2014). Asymmetric synthesis of 5,6-dihydro-2H-pyran-2-one derivatives. Unpublished doctoral dissertation, İzmir Institute of Technology, İzmir, Turkeyen_US
dc.descriptionThesis (Doctoral)--İzmir Institute of Technology, Chemistry, İzmir, 2014en_US
dc.descriptionFull text release delayed at author's request until 2017.11.12en_US
dc.descriptionIncludes bibliographical references (leaves: 108-113)en_US
dc.descriptionText in English; Abstract: Turkish and Englishen_US
dc.descriptionxvii, 122 leavesen_US
dc.description.abstractα,β-unsaturated lactone derivatives are very important structural core which are isolated from nature and shown as source for several biological activities. Biologically active styryl δ-lactones are well known α,β-unsaturated-δ-lactones. Up to date, many α,β- unsaturated-δ-lactones and their analogues have been isolated and synthesized, exhibiting promising anti-proliferative properties against different cancer cell lines. In this thesis, large scale asymmetric syntheses of (R)-4’-methylklavuzon and (R)- 2’-methylklavuzon were completed successfully. Also, syntheses of heteroatom functionalized naphthyl substituted novel α,β-unsaturated-δ-lactone (5,6-dihydro-2Hpyran- 2-one) derivatives, α,β-unsaturated-γ-lactone (furan-2(5H)-one) derivatives and 7- membered α,β-unsaturated lactone (6,7-dihydro-5H-oxepin-2-one) derivatives were accomplished. Development of a method for one-pot synthesis of 6-membered α,β-unsaturated- δ-lactone was also studied, and a new vinylogous aldol addition method was developed. By this method, new α,β-unsaturated methyl esters were prepared via dienolate formation starting with methyl buten-3-oate.en_US
dc.description.sponsorshipTÜBİTAK project (110T782)en_US
dc.publisherIzmir Institute of Technologyen_US
dc.subjectAsymmetric synthesisen_US
dc.subjectα,β-unsaturated lactoneen_US
dc.titleAsymmetric synthesis of 5,6-dihydro-2H-pyran-2-one derivativesen_US
dc.title.alternative5,6-dihidro-2H-piran-2-on türevlerinin asimetrik sentezien_US
dc.typeDoctoral Thesisen_US
dc.institutionauthorAkçok, İsmail-
dc.departmentThesis (Doctoral)--İzmir Institute of Technology, Chemistryen_US
item.fulltextWith Fulltext-
item.openairetypeDoctoral Thesis-
Appears in Collections:Phd Degree / Doktora
Files in This Item:
File Description SizeFormat 
T001326.pdfDoctoralThesis2.99 MBAdobe PDFThumbnail
Show simple item record

CORE Recommender

Page view(s)

checked on May 22, 2023


checked on May 22, 2023

Google ScholarTM


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.