Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/4678
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dc.contributor.authorGelal, Ayşe-
dc.contributor.authorGüven, Hülya-
dc.contributor.authorBalkan, Dilara-
dc.contributor.authorArtok, Levent-
dc.contributor.authorBenowitz, Neal L.-
dc.date.accessioned2016-05-30T07:43:57Z
dc.date.available2016-05-30T07:43:57Z
dc.date.issued2003-09
dc.identifier.citationGelal, A., Güven, H., Balkan, D., Artok, L., and Benowitz, N. L. (2003). Influence of menthol on caffeine disposition and pharmacodynamics in healthy female volunteers. European Journal of Clinical Pharmacology, 59(5-6), 417-422. doi:10.1007/s00228-003-0631-1en_US
dc.identifier.issn0031-6970
dc.identifier.issn0031-6970-
dc.identifier.urihttp://doi.org/10.1007/s00228-003-0631-1
dc.identifier.urihttp://hdl.handle.net/11147/4678
dc.description.abstractObjectives: The present study was undertaken to determine whether a single oral dose of menthol affects the metabolism of caffeine, a cytochrome P 450 1A2 (CYP1A2) substrate, and pharmacological responses to caffeine in people. Methods: Eleven healthy female subjects participated in a randomized, double-blind, two-way crossover study, comparing the kinetics and effects of a single oral dose of caffeine (200 mg) in coffee taken together with a single oral dose of menthol (100 mg) or placebo capsules. Serum caffeine concentrations and cardiovascular and subjective parameters were measured throughout the study. Results: Co-administration of menthol resulted in an increase of caffeine tmax values from 43.6 ± 20.6 min (mean ± SD) to 76.4 ± 28.0 min (P<0.05). The Cmax values of caffeine were lower in the menthol phase than in the placebo phase, but this effect was not statistically significant (P=0.06). (AUG)0-24, (AUC)0-∞, terminal half-life and oral clearance were not affected by menthol. Only nine subjects' cardiovascular data were included in the analysis because of technical problems during the measurements. After caffeine, heart rate decreased in both treatment phases. The maximum decrease in heart rate was less in the menthol phase (-8.9 ± 3.9 beats/min) than in the placebo phase (-13.1 ± 2.1 beats/min) (P = 0.024). There were no statistically significant differences in systolic and diastolic blood pressures between the two treatments. Conclusions: We conclude that a single oral dose of pure menthol (100 mg) delays caffeine absorption and blunts the heart-rate slowing effect of caffeine, but does not affect caffeine metabolism. The possibility that menthol slows the absorption of other drugs should be considered.en_US
dc.description.sponsorshipDokuz Eylul University Research Foundation (project no: 0909.99.02.16)en_US
dc.language.isoenen_US
dc.publisherSpringer Verlagen_US
dc.relation.ispartofEuropean Journal of Clinical Pharmacologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCaffeineen_US
dc.subjectMentholen_US
dc.subjectMonoterpenesen_US
dc.subjectControlled clinical trialen_US
dc.titleInfluence of menthol on caffeine disposition and pharmacodynamics in healthy female volunteersen_US
dc.typeArticleen_US
dc.authoridTR1860en_US
dc.institutionauthorArtok, Levent-
dc.departmentIzmir Institute of Technology. Chemistryen_US
dc.identifier.volume59en_US
dc.identifier.issue5-6en_US
dc.identifier.startpage417en_US
dc.identifier.endpage422en_US
dc.identifier.wosWOS:000185415200012en_US
dc.identifier.scopus2-s2.0-0141594697en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s00228-003-0631-1-
dc.identifier.pmid12915954en_US
dc.relation.doi10.1007/s00228-003-0631-1en_US
dc.coverage.doi10.1007/s00228-003-0631-1en_US
dc.identifier.scopusqualityQ1-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.dept04.01. Department of Chemistry-
Appears in Collections:Chemistry / Kimya
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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