Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/4746
Title: Determination of thiamine HCl and pyridoxine HCl in pharmaceutical preparations using UV-Visible spectrophotometry and genetic algorithm based multivariate calibration methods
Authors: Özdemir, Durmuş
Dinç, Erdal
Keywords: Classical Least Squares
Genetic algorithms
Genetic regression
Inverse Least Squares
Multivariate calibration
Issue Date: Jul-2004
Publisher: Pharmaceutical Society of Japan
Source: Özdemir, D., and Dinç, E. (2004). Determination of thiamine HCl and pyridoxine HCl in pharmaceutical preparations using UV-Visible spectrophotometry and genetic algorithm based multivariate calibration methods. Chemical and Pharmaceutical Bulletin, 52(7), 810-817. doi:10.1248/cpb.52.810
Abstract: Simultaneous determination of binary mixtures pyridoxine hydrochloride and thiamine hydrochloride in a vitamin combination using UV-visible spectrophotometry and classical least squares (CLS) and three newly developed genetic algorithm (GA) based multivariate calibration methods was demonstrated. The three genetic multivariate calibration methods are Genetic Classical Least Squares (GCLS), Genetic Inverse Least Squares (GILS) and Genetic Regression (GR). The sample data set contains the UV-visible spectra of 30 synthetic mixtures (8 to 40 μg/ml) of these vitamins and 10 tablets containing 250 mg from each vitamin. The spectra cover the range from 200 to 330 nm in 0.1 nm intervals. Several calibration models were built with the four methods for the two components. Overall, the standard error of calibration (SEC) and the standard error of prediction (SEP) for the synthetic data were in the range of <0.01 and 0.43 μg/ml for all the four methods. The SEP values for the tablets were in the range of 2.91 and 11.51 mg/tablets. A comparison of genetic algorithm selected wavelengths for each component using GR method was also included
URI: http://doi.org/10.1248/cpb.52.810
http://hdl.handle.net/11147/4746
ISSN: 0009-2363
0009-2363
Appears in Collections:Chemistry / Kimya
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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