Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/4796
Title: Multidrug resistance mediated by MRP1 gene overexpression in breast cancer patients
Authors: Abaan, Ogan Demir
Mutlu, Pelin Kaya
Baran, Yusuf
Atalay, Can
Gündüz, Ufuk
Keywords: Breast cancer
Chemotherapy
MDR
MRP Family
MRP1
Issue Date: Feb-2009
Publisher: Taylor and Francis Ltd.
Source: Abaan, O. D., Mutlu, P. K., Baran, Y., Atalay, C. and Gündüz, U. (2009). Multidrug resistance mediated by MRP1 gene overexpression in breast cancer patients. Cancer Investigation, 27(2), 201-205. doi:10.1080/07357900802173562
Abstract: Multidrug resistance (MDR) is a serious handicap towards the effective treatment of breast cancer patients. One of the most prevalent MDR mechanisms is through the overexpression of genes coding the proteins called Multidrug Resistance-associated Proteins (MRPs). The aim of this study was to investigate the expression of MRP1 in tumor tissues from breast cancer patients. In this study, a semi-quantitative RT-PCR approach was utilized. Our results suggest that MRP1 overexpression can mediate MDR in patients. Pre-evaluation of the level of such MDR mediators before chemotherapy can increase the efficacy of the treatment.
URI: http://dx.doi.org/10.1080/07357900802173562
http://hdl.handle.net/11147/4796
ISSN: 0735-7907
0735-7907
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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