Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/4827
Title: Role of autophagy in the progression and suppression of leukemias
Authors: Ekiz, Hüseyin Atakan
Can, Geylani
Baran, Yusuf
Keywords: Leukemia
Chemotherapeutic resistance
Cell death
Autophagy
Issue Date: Mar-2012
Publisher: Elsevier Ltd.
Source: Ekiz, H. A., Can, G., and Baran, Y. (2012). Role of autophagy in the progression and suppression of leukemias. Critical Reviews in Oncology/Hematology, 81(3), 275-285. doi:10.1016/j.critrevonc.2011.03.009
Abstract: Autophagy is a physiological process in which cellular components are degraded by the lysosomal machinery. Thereby, organelles are recycled and monomers are produced in order to maintain energy production. Current studies indicate autophagy might suppress or augment survival of cancer cells. Therefore, by elucidating the role of autophagy in cancer pathogenesis, novel therapeutic intervention points may be revealed. Leukemia therapy has advanced in recent years; but a definitive cure is still lacking. Since autophagy often is deregulated in this particular type of cancer, it is clear that future findings will have clinical implications. This review will discuss the current knowledge of autophagy in blood cancers. © 2011 Elsevier Ireland Ltd.
URI: http://doi.org/10.1016/j.critrevonc.2011.03.009
http://hdl.handle.net/11147/4827
ISSN: 1040-8428
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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