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Title: Effects of surface functional groups on the aggregation stability of magnetite nanoparticles in biological media containing serum
Authors: Wiogo, Hilda T. R.
Lim, May
Bulmuş, Volga
Amal, Rose
Keywords: Agglomeration
Gel electrophoresis
Magnetite nanoparticles
Protein corona
Publisher: Institute of Electrical and Electronics Engineers Inc.
Source: Wiogo, H. T. R., Lim, M., Bulmuş, V., and Amal, R. (2011, August 15-19). Effects of surface functional groups on the aggregation stability of magnetite nanoparticles in biological media containing serum. Paper presented at the 11th IEEE International Conference on Nanotechnology. doi:10.1109/NANO.2011.6144499
Abstract: Size stability of magnetite nanoparticles (MNP) with different surface functional groups in biological media was achieved by the addition of fetal bovine serum (FBS). The stability of the particles was attributed to the formation of protein coronas around the particles, which provides sufficient steric hindrance to prevent aggregation of the particles. The stability of different modified MNP were also studied in biological media containing bovine serum albumin (BSA) to further understand the stabilization mechanism. BSA was found to stabilize polyethyleneimine (PEI) modified MNP and polymethacrylic acid (PMAA) coated MNP, but not the bare MNP. These results indicate a difference in interactions between serum protein and the MNP that is govern by the type of functional groups on the MNP surface, with positively charged surface groups resulting higher protein adsorption and better stability. © 2011 IEEE.
Description: 11th IEEE International Conference on Nanotechnology, NANO 2011; Portland, OR; United States; 15 August 2011 through 19 August 2011
ISBN: 9781457715143
ISSN: 1944-9399
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

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