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https://hdl.handle.net/11147/4950
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DC Field | Value | Language |
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dc.contributor.author | Avcı, Çığır Biray | - |
dc.contributor.author | Yılmaz, Sunde | - |
dc.contributor.author | Doğan, Zeynep Özlem | - |
dc.contributor.author | Saydam, Güray | - |
dc.contributor.author | Dodurga, Yavuz | - |
dc.contributor.author | Ekiz, Hüseyin Atakan | - |
dc.contributor.author | Kartal, Melis | - |
dc.contributor.author | Şahin, Fahri | - |
dc.contributor.author | Baran, Yusuf | - |
dc.contributor.author | Gündüz, Cumhur | - |
dc.date.accessioned | 2017-03-02T10:34:40Z | |
dc.date.available | 2017-03-02T10:34:40Z | |
dc.date.issued | 2011-09 | |
dc.identifier.citation | Avcı, Ç. B., Yılmaz, S., Doğan, Z.Ö., Saydam, G., Dodurga, Y., Ekiz, H. A., Kartal, M., Şahin, F., Baran, Y., and Gündüz, C. (2011). Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells. Hematology, 16(6) , 303-307. doi:10.1179/102453311X13085644680104 | en_US |
dc.identifier.issn | 1024-5332 | |
dc.identifier.issn | 1024-5332 | - |
dc.identifier.uri | http://doi.org/10.1179/102453311X13085644680104 | |
dc.identifier.uri | http://hdl.handle.net/11147/4950 | |
dc.description.abstract | We aimed to examine the growth suppressive effects of quercetin on acute promyelocytic and lymphoblastic leukemia and chronic myeloid leukemia, and to find out whether the growth suppression is related to the blocking of telomerase enzyme activity. Cytotoxic effects of quercetin were shown by trypan blue analyses. Apoptotic effects of quercetin were examined by acridine orange and ethidium bromide staining by fluorescence microscopy. The effects of quercetin on telomerase enzyme activity were shown by hTERT Quantification Kit. Our results demonstrated that quercetin has antiproliferative and apoptotic effects on T-cell acute lymphoblastic leukemia (ALL), acute promyelocytic leukemia, and chronic myeloid leukemia (CML) cells. We also showed for the first time by this study that quercetin suppresses the activity of telomerase in ALL and CML cells. The results of this study show the importance of quercetin for its therapeutic potential in treatment of leukemias. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Taylor and Francis Ltd. | en_US |
dc.relation.ispartof | Hematology | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | hTERT | en_US |
dc.subject | Leukemia | en_US |
dc.subject | Quercetin | en_US |
dc.subject | Telomerase | en_US |
dc.title | Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells | en_US |
dc.type | Article | en_US |
dc.authorid | TR119193 | en_US |
dc.institutionauthor | Ekiz, Hüseyin Atakan | - |
dc.institutionauthor | Kartal, Melis | - |
dc.institutionauthor | Baran, Yusuf | - |
dc.department | İzmir Institute of Technology. Molecular Biology and Genetics | en_US |
dc.identifier.volume | 16 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 303 | en_US |
dc.identifier.endpage | 307 | en_US |
dc.identifier.wos | WOS:000294495000008 | en_US |
dc.identifier.scopus | 2-s2.0-80052590432 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1179/102453311X13085644680104 | - |
dc.identifier.pmid | 21902895 | en_US |
dc.relation.doi | 10.1179/102453311X13085644680104 | en_US |
dc.coverage.doi | 10.1179/102453311X13085644680104 | en_US |
dc.identifier.wosquality | Q4 | - |
dc.identifier.scopusquality | Q3 | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 04.03. Department of Molecular Biology and Genetics | - |
crisitem.author.dept | 04.03. Department of Molecular Biology and Genetics | - |
Appears in Collections: | Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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