Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5173
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBozkurt, Süreyya-
dc.contributor.authorÖzkan, Tülin-
dc.contributor.authorÖzmen, Füsun-
dc.contributor.authorBaran, Yusuf-
dc.contributor.authorSunguroglu, Asuman-
dc.contributor.authorKansu, Emin-
dc.date.accessioned2017-03-29T07:44:29Z
dc.date.available2017-03-29T07:44:29Z
dc.date.issued2013-07
dc.identifier.citationBozkurt, S., Özkan, T., Özmen, F., Baran, Y., Sunguroğlu, A., and Kansu, E. (2013). The roles of epigenetic modifications of proapoptotic BID and BIM genes in imatinibresistant chronic myeloid leukemia cells. Hematology, 18(4), 217-223. doi:10.1179/1607845412Y.0000000056en_US
dc.identifier.issn1024-5332
dc.identifier.issn1024-5332-
dc.identifier.urihttps://doi.org/10.1179/1607845412Y.0000000056
dc.identifier.urihttp://hdl.handle.net/11147/5173
dc.description.abstractIn chronic myeloid leukemia (CML), epigenetic modifications such as promoter hypermethylation and inactive histone modification are known mechanisms of drug resistance. In our study, we investigated the roles of promoter hypermethylation of BIM and BID genes and H3K27me3 histone modification on imatinib resistance. We detected higher expression levels of BIM and BID genes and lower expression levels of EZH2, EED2, SIRT1, and SUZ12 genes in imatinib-resistant K562/IMA-3 cells compared to imatinib-non-resistant K562 cells. While we determined the EZH2 and DNMT enzymes as bounded to the promoter of the BIM gene, we did not detect hypermethylation of this promoter. We also found the H3K27me3 histone modification promoter of BIM and BID genes in both cell lines. In conclusion, our results support the notion that DNA promoter methylation may be formed independently from EZH2-H3K27me3 and pro-apoptotic BIM and BID genes are not methyllated in the imatinib resistance of CML cells.en_US
dc.description.sponsorshipTUBITAK-SBAG (109S285); Turkish Academy of Sciences (TUBA)en_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relationinfo:eu-repo/grantAgreement/TUBITAK/SBAG/109S285en_US
dc.relation.ispartofHematologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCMLen_US
dc.subjectEpigeneticen_US
dc.subjectPolicomb group proteinsen_US
dc.subjectDNA methylationen_US
dc.subjectCancer cellsen_US
dc.subjectChronic myeloid leukemiaen_US
dc.titleThe roles of epigenetic modifications of proapoptotic BID and BIM genes in imatinibresistant chronic myeloid leukemia cellsen_US
dc.typeArticleen_US
dc.authoridTR119193en_US
dc.institutionauthorBaran, Yusuf-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume18en_US
dc.identifier.issue4en_US
dc.identifier.startpage217en_US
dc.identifier.endpage223en_US
dc.identifier.wosWOS:000321554200006en_US
dc.identifier.scopus2-s2.0-84880011788en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1179/1607845412Y.0000000056-
dc.identifier.pmid23394612en_US
dc.relation.doi10.1179/1607845412Y.0000000056en_US
dc.coverage.doi10.1179/1607845412Y.0000000056en_US
dc.identifier.wosqualityQ4-
dc.identifier.scopusqualityQ1-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairetypeArticle-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Files in This Item:
File Description SizeFormat 
5173.pdfMakale232.08 kBAdobe PDFThumbnail
View/Open
Show simple item record



CORE Recommender

SCOPUSTM   
Citations

10
checked on Apr 5, 2024

WEB OF SCIENCETM
Citations

9
checked on Mar 27, 2024

Page view(s)

160
checked on Apr 15, 2024

Download(s)

216
checked on Apr 15, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.