Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5204
Title: 6-Bicycloaryl substituted (S)- and (R)-5,6-dihydro-2H-pyran-2-ones: Asymmetric synthesis, and anti-proliferative properties
Authors: Kasaplar, Pınar
Yılmazer, Özgür
Çağır, Ali
Keywords: (R)-Goniothalamin
Cancer cell lines
Conformationally constrained analogues
Cytotoxic activity
Issue Date: Jan-2009
Publisher: Elsevier Ltd.
Source: Kasaplar, P., Yılmazer, Ö. and Çağır, A.(2009). 6-Bicycloaryl substituted (S)- and (R)-5,6-dihydro-2H-pyran-2-ones: Asymmetric synthesis, and anti-proliferative properties. Bioorganic and Medicinal Chemistry, 17(1), 311-318. doi:10.1016/j.bmc.2008.10.069
Abstract: (R)-Goniothalamin, is a member of styryl lactones, possesses selective cytotoxicity against cancer cell lines. In this work, replacement of styryl substituent with 2-naphthyl and 3-quinoyl gave new analogues which may have less conformational changes compared to the lead compound. Anti-proliferative tests indicated that 2-naphthyl substituted (R)-5,6-dihydro-2H-pyran-2-one has slightly better cytotoxicity than (R)-goniothalamin. To clarify the effect of 2-naphthyl substituent additional aryl substituted (R)-5,6-dihydro-2H-pyran-2-ones have been synthesized enantioselectively and tested against PC-3 and MCF-7 cell lines.
URI: http://dx.doi.org/10.1016/j.bmc.2008.10.069
http://hdl.handle.net/11147/5204
ISSN: 0968-0896
0968-0896
Appears in Collections:Chemistry / Kimya
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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