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Title: Can MiRBase provide positive data for machine learning for the detection of MiRNA hairpins?
Authors: Demirci, Müşerref Duygu Saçar
Hamzeiy, Hamid
Allmer, Jens
Keywords: MicroRNAs
Sequence alignment
Molecular sequence data
Nucleic acid
Issue Date: 2013
Publisher: Informationsmanagement in der Biotechnologie e.V. (IMBio e.V.)
Source: Saçar, M. D., Hamzeiy, H., and Allmer, J. (2013). Can MiRBase provide positive data for machine learning for the detection of MiRNA hairpins? Journal of integrative bioinformatics, 10(2). doi:10.2390/biecoll-jib-2013-215
Abstract: Experimental detection and validation of miRNAs is a tedious, time-consuming, and expensive process. Computational methods for miRNA gene detection are being developed so that the number of candidates that need experimental validation can be reduced to a manageable amount. Computational methods involve homology-based and ab inito algorithms. Both approaches are dependent on positive and negative training examples. Positive examples are usually derived from miRBase, the main resource for experimentally validated miRNAs. We encountered some problems with miRBase which we would like to report here. Some problems, among others, we encountered are that folds presented in miRBase are not always the fold with the minimum free energy; some entries do not seem to conform to expectations of miRNAs, and some external accession numbers are not valid. In addition, we compared the prediction accuracy for the same negative dataset when the positive data came from miRBase or miRTarBase and found that the latter led to more precise prediction models. We suggest that miRBase should introduce some automated facilities for ensuring data quality to overcome these problems.
ISSN: 1613-4516
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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