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Title: STAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cells
Authors: Kiper, Hatice Demet
Tezcanlı Kaymaz, Burçin
Adan Gökbulut, Aysun
Selvi, Nur
Biray Avcı, Çığır
Kosova, Buket
İskender, Güniz
Kartal Yandım, Melis
Gündüz, Cumhur
Şahin, Fahri
Baran, Yusuf
Saydam, Güray
Keywords: Zoledronic acid
Chronic myeloid leukemia
Messenger RNA
Issue Date: Jul-2013
Publisher: Elsevier Ltd.
Source: Kiper, H. D., Tezcanlı Kaymaz, B., Adan Gökbulut, A., Selvi, N., Biray Avcı, Ç., Kosova, B., İskender, G., Kartal Yandım, M., Gündüz, C., Şahin, F., Baran, Y., and Saydam, G. (2013). STAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cells. Biomedicine and Pharmacotherapy, 67(6), 527-532. doi:10.1016/j.biopha.2013.04.006
Abstract: In this study, we aimed to evaluate the cytotoxic and apoptotic effects of zoledronic acid on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on zoledronic acid-induced apoptosis. The results showed that zoledronic acid decreased proliferation, and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT3, -5A and -5B genes were significantly reduced in zoledronic acid-treated K562 cells. These data indicated that STAT inhibition by zoledronic acid may be therapeutic in CML patients following the confirmation with clinical studies. © 2013 Elsevier Masson SAS.
ISSN: 0753-3322
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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