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Title: Multidrug resistance in chronic myeloid leukemia
Authors: Ünlü, Miray
Kiraz, Yağmur
Kacı, Fatma Necmiye
Özcan, Mehmet Ali
Baran, Yusuf
Keywords: Tyrosine kinase inhibitor
Drug resistance
Chronic myeloid leukemia
Cancer cells
BCR-ABL protein
Issue Date: 2014
Publisher: TÜBİTAK
Source: Ünlü, M., Kiraz, Y., Kacı, F. N., Özcan, M. A., and Baran, Y. (2014). Multidrug resistance in chronic myeloid leukemia. Turkish Journal of Biology, 38(6), 806-816. doi:10.3906/biy-1405-21
Abstract: Chronic myeloid leukemia (CML) is characterized by the accumulation of Philadelphia chromosome-positive (Ph+) myeloid cells. Ph+ cells occur via a reciprocal translocation between the long arms of chromosomes 9 and 22 resulting in constitutively active Bcr-abl fusion protein. Tyrosine kinase inhibitors (TKIs) are used against the kinase activity of Bcr-abl fusion protein for the effective treatment of CML. However, the development of drug resistance, directed by different genetic mechanisms, is the major problem of clinical applications of TKIs. These mechanisms include mutations in the TKI binding site of Bcr-abl, overexpression of Bcr-abl, overexpression of ATP binding cassette transporters, aberrant ceramide metabolism, inhibition of apoptosis, and changes in expression levels of microRNAs. Recently, many studies have focused on understanding the molecular mechanisms of drug resistance in cancer while targeting therapies providing reversal of resistance. Cancer stem cells also have roles in tumor initiation, maintenance, progression, metastasis, and drug resistance. Uncovering the mechanisms of drug resistance can provide more efficient treatment of cancer since these findings may provide novel targets for a complete cure. In this review, we discuss recent findings on the mechanisms of multidrug resistance and its reversal in CML. © TÜBİTAK.
ISSN: 1300-0152
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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