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Title: Apoptotic effects of quercitrin on DLD-1 colon cancer cell line
Authors: Çinçin, Zeynep Birsu
Ünlü, Miray
Kıran, Bayram
Bireller, Elif Sinem
Baran, Yusuf
Çakmakoğlu, Bedia
Keywords: Antiproliferative
Colon cancer
Antineoplastic agent
Issue Date: Aug-2014
Publisher: Springer Verlag
Source: ÇinÇin, Z.B., Ünlü, M., Kıran, B., Bireller, E.S., Baran, Y., and Çakmakoğlu, B. (2014). Apoptotic effects of quercitrin on DLD-1 colon cancer cell line. Pathology and Oncology Research, 21(2), 333-338. doi:10.1007/s12253-014-9825-3
Abstract: Quercetin, which is the most abundant bioflavonoid compound, is mainly present in the glycoside form of quercitrin. Although different studies indicated that quercitrin is a potent antioxidant, the action of this compound is not well understood. In this study, we investigated whether quercitrin has apoptotic and antiproliferative effects in DLD-1 colon cancer cell lines. Time and dose dependent antiproliferative and apoptotic effects of quercitrin were subsequently determined by WST-1 cell proliferation assay, lactate dehydrogenase (LDH) cytotoxicity assay, detection of nucleosome enrichment factor, changes in caspase-3 activity, loss of mitochondrial membrane potential (MMP) and also the localization of phosphatidylserine (PS) in the plasma membrane. There were significant increases in caspase-3 activity, loss of MMP, and increases in the apoptotic cell population in response to quercitrin in DLD-1 colon cancer cells in a time- and dose-dependent manner. These results revealed that quercitrin has antiproliferative and apoptotic effects on colon cancer cells. Quercitrin activity supported with in vivo analyses could be a biomarker candicate for early colorectal carcinoma.
ISSN: 1219-4956
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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