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https://hdl.handle.net/11147/5417
Title: | Apoptotic effects of quercitrin on DLD-1 colon cancer cell line | Authors: | Çinçin, Zeynep Birsu Ünlü, Miray Kıran, Bayram Bireller, Elif Sinem Baran, Yusuf Çakmakoğlu, Bedia |
Keywords: | Antiproliferative Apoptosis Quercitrin Colon cancer Antineoplastic agent |
Publisher: | Springer Verlag | Source: | ÇinÇin, Z.B., Ünlü, M., Kıran, B., Bireller, E.S., Baran, Y., and Çakmakoğlu, B. (2014). Apoptotic effects of quercitrin on DLD-1 colon cancer cell line. Pathology and Oncology Research, 21(2), 333-338. doi:10.1007/s12253-014-9825-3 | Abstract: | Quercetin, which is the most abundant bioflavonoid compound, is mainly present in the glycoside form of quercitrin. Although different studies indicated that quercitrin is a potent antioxidant, the action of this compound is not well understood. In this study, we investigated whether quercitrin has apoptotic and antiproliferative effects in DLD-1 colon cancer cell lines. Time and dose dependent antiproliferative and apoptotic effects of quercitrin were subsequently determined by WST-1 cell proliferation assay, lactate dehydrogenase (LDH) cytotoxicity assay, detection of nucleosome enrichment factor, changes in caspase-3 activity, loss of mitochondrial membrane potential (MMP) and also the localization of phosphatidylserine (PS) in the plasma membrane. There were significant increases in caspase-3 activity, loss of MMP, and increases in the apoptotic cell population in response to quercitrin in DLD-1 colon cancer cells in a time- and dose-dependent manner. These results revealed that quercitrin has antiproliferative and apoptotic effects on colon cancer cells. Quercitrin activity supported with in vivo analyses could be a biomarker candicate for early colorectal carcinoma. | URI: | https://doi.org/10.1007/s12253-014-9825-3 http://hdl.handle.net/11147/5417 |
ISSN: | 1219-4956 1532-2807 1219-4956 |
Appears in Collections: | Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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