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Title: A BODIPY-based reactive probe for the detection of Au(iii) species and its application to cell imaging
Authors: Üçüncü, Muhammed
Emrullahoğlu, Mustafa
Keywords: Gold
Fluorescent dye
Hydrazone derivative
Metal ion
Boron derivative
Publisher: Royal Society of Chemistry
Source: Üçüncü, M., and Emrullahoǧlu, M. (2014). A BODIPY-based reactive probe for the detection of Au(iii) species and its application to cell imaging. Chemical Communications, 50(44), 5884-5886. doi:10.1039/c4cc01958j
Abstract: A BODIPY-based fluorescent probe bearing a pyridyl hydrazone motif responds selectively to Au(III) ions through an irreversible C[double bond, length as m-dash]N bond hydrolysis reaction. Gold species, besides their ability to catalyse chemical transformations in organic synthesis,1 have significant impacts on human health.2,3 Gold-based drugs have long been used in the treatment of rheumatoid arthritis and other autoimmune diseases.2 At the same time, when accumulated in the biological system at certain concentrations, gold species have the potential to disturb a series of cellular processes by irreversible interaction with biomolecules.3 In recent years, fluorescence-based sensing has become an indispensable tool for sensitive and accurate detection of trace levels of metal species in the solution.4 In addition, with the aid of fluorescence microscopy it has become possible to track metal species in living cells, which is of crucial importance for elucidating their roles in the biological system.
ISSN: 1359-7345
Appears in Collections:Chemistry / Kimya
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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