Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5431
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dc.contributor.authorBarlas, Fırat Barış-
dc.contributor.authorAğ Şeleci, Didem-
dc.contributor.authorÖzkan, Melek-
dc.contributor.authorDemir, Bilal-
dc.contributor.authorŞeleci, Muharrem-
dc.contributor.authorAydın, Muhammed-
dc.contributor.authorTaşdelen, M. A.-
dc.contributor.authorZareie, Hadi M.-
dc.contributor.authorTimur, Suna-
dc.contributor.authorÖzçelik, Serdar-
dc.contributor.authorYağcı, Yusuf-
dc.date.accessioned2017-04-28T07:38:08Z-
dc.date.available2017-04-28T07:38:08Z-
dc.date.issued2014-10-
dc.identifier.citationBarlas, F. B., Ağ Şeleci, D., Özkan, M., Demir, B., Şeleci, M., Aydın, M., Taşdelen, M. A., Zareie, H. M., Timur, S., Özçelik, S. and Yağcı, Y. (2014). Folic acid modified clay/polymer nanocomposites for selective cell adhesion. Journal of Materials Chemistry B, 2(37), 6412-6421. doi:10.1039/c4tb00850ben_US
dc.identifier.issn2050-7518-
dc.identifier.urihttp://doi.org/10.1039/c4tb00850b-
dc.identifier.urihttp://hdl.handle.net/11147/5431-
dc.description.abstractA folic acid (FA) modified poly(epsilon-caprolactone)/clay nanocomposite (PCL/MMT-(CH2CH2OH)2-FA) resulting in selective cell adhesion and proliferation was synthesized and characterized as a cell culture and biosensing platform. For this purpose, first the FA modified clay (MMT-(CH2CH2OH)2-FA) was prepared by treating the organo-modified clay, Cloisite 30B [MMT-(CH2CH 2OH)2] with FA in chloroform at 60°C. Subsequent ring opening polymerization of ε-caprolactone in the presence of tin octoate (Sn(Oct)2) using MMT-(CH2CH2OH)2-FA at 110°C resulted in the formation of MMT-(CH2CH 2OH)2-FA with an exfoliated clay structure. The structures of intermediates and the final nanocomposite were investigated in detail by FT-IR spectral analysis and DSC, TGA, XRD, SEM and AFM measurements. The combination of FA, PCL and clay provides a simple and versatile route to surfaces that allows controlled and selective cell adhesion and proliferation. FA receptor-positive HeLa and negative A549 cells were used to prove the selectivity of the modified surfaces. Both microscopy and electrochemical sensing techniques were applied to show the differences in cell adherence on the modified and pristine clay platforms. This approach is expected to be adapted into various bio-applications such as 'cell culture on chip', biosensors and design of tools for targeted diagnosis or therapy.en_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.ispartofJournal of Materials Chemistry Ben_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectClaysen_US
dc.subjectPolymersen_US
dc.subjectNanocompositesen_US
dc.subjectFolic aciden_US
dc.subjectCell adhesionen_US
dc.subjectBiomedical researchen_US
dc.titleFolic acid modified clay/polymer nanocomposites for selective cell adhesionen_US
dc.typeArticleen_US
dc.authoridTR7497en_US
dc.institutionauthorÖzkan, Melek-
dc.institutionauthorZareie, Hadi M.-
dc.institutionauthorÖzçelik, Serdar-
dc.departmentİzmir Institute of Technology. Chemistryen_US
dc.identifier.volume2en_US
dc.identifier.issue37en_US
dc.identifier.startpage6412en_US
dc.identifier.endpage6421en_US
dc.identifier.wosWOS:000341457500028en_US
dc.identifier.scopus2-s2.0-84907076930en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1039/c4tb00850b-
dc.identifier.pmid32262158en_US
dc.relation.doi10.1039/c4tb00850ben_US
dc.coverage.doi10.1039/c4tb00850ben_US
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept04.01. Department of Chemistry-
Appears in Collections:Chemistry / Kimya
Materials Science and Engineering / Malzeme Bilimi ve Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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