Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5495
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dc.contributor.authorMutlu, Pelin-
dc.contributor.authorKiraz, Yağmur-
dc.contributor.authorGündüz, Ufuk-
dc.contributor.authorBaran, Yusuf-
dc.date.accessioned2017-05-12T13:39:34Z-
dc.date.available2017-05-12T13:39:34Z-
dc.date.issued2015-12-
dc.identifier.citationMutlu, P., Kiraz, Y., Gündüz, U., and Baran, Y. (2015). An update on molecular biology and drug resistance mechanisms of multiple myeloma. Critical Reviews in Oncology/Hematology, 96(3), 413-424. doi:10.1016/j.critrevonc.2015.07.003en_US
dc.identifier.issn1040-8428-
dc.identifier.urihttp://doi.org/10.1016/j.critrevonc.2015.07.003-
dc.identifier.urihttp://hdl.handle.net/11147/5495-
dc.description.abstractMultiple myeloma (MM), a neoplasm of plasma cells, is the second most common hematological malignancy. Incidance rates increase after age 40. MM is most commonly seen in men and African-American population. There are several factors to this, such as obesity, environmental factors, family history, genetic factors and monoclonal gammopathies of undetermined significance (MGUS) that have been implicated as potentially etiologic. Development of MM involves a series of complex molecular events, including chromosomal abnormalities, oncogene activation and growth factor dysregulation. Chemotherapy is the most commonly used treatment strategy in MM. However, MM is a difficult disease to treat because of its marked resistance to chemotherapy. MM has been shown to be commonly multidrug resistance (MDR)-negative at diagnosis and associated with a high incidence of MDR expression at relapse. This review deals with the molecular aspects of MM, drug resistance mechanisms during treatment and also possible new applications for overcoming drug resistance. © 2015 Elsevier Ireland Ltd.en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofCritical Reviews in Oncology/Hematologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDrug resistanceen_US
dc.subjectMolecular aspectsen_US
dc.subjectMultiple myelomaen_US
dc.subjectTargeted drug deliveryen_US
dc.titleAn update on molecular biology and drug resistance mechanisms of multiple myelomaen_US
dc.typeArticleen_US
dc.authorid0000-0003-3508-5617en_US
dc.institutionauthorKiraz, Yağmur-
dc.institutionauthorBaran, Yusuf-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume96en_US
dc.identifier.issue3en_US
dc.identifier.startpage413en_US
dc.identifier.endpage424en_US
dc.identifier.wosWOS:000366536800003en_US
dc.identifier.scopus2-s2.0-84959125071en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.critrevonc.2015.07.003-
dc.identifier.pmid26235594en_US
dc.relation.doi10.1016/j.critrevonc.2015.07.003en_US
dc.coverage.doi10.1016/j.critrevonc.2015.07.003en_US
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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