Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5556
Title: Decreased expression of EFS is correlated with the advanced prostate cancer
Authors: Sertkaya, Selda
Hamid, Syed Muhammad
Dilsiz, Nihat
Varışlı, Lokman
Keywords: Prostate cancer
DNA methylation
Embryonal Fyn-associated substrate
Tumor
Issue Date: Feb-2015
Publisher: SAGE Publications Inc.
Source: Sertkaya, S., Hamid, S. M., Dilsiz, N., and Varışlı, L. (2015). Decreased expression of EFS is correlated with the advanced prostate cancer. Tumor Biology, 36(2), 799-805. doi:10.1007/s13277-014-2703-5
Abstract: Prostate cancer is the most frequently diagnosed malignant neoplasm in men in the developed countries. Although the progression of prostate cancer and the processes of invasion and metastasis by tumor cells are comparatively well understood, the genes involved in these processes are not fully determined. Therefore, a common area of research interest is the identification of novel molecules that are involved in these processes. In the present study, we have used in silico and experimental approaches to compare the expression of embryonal Fyn-associated substrate (EFS) between normal prostate and prostate cancer. We showed that EFS expression is remarkably downregulated in prostate cancer cells, compared to normal prostate cells. We also found that decreased expression of EFS in prostate cancer cells is due to DNA methylation. In addition, we showed that high EFS expression is important to suppress a malignant behavior of prostate cancer cells. Therefore, we suggest that EFS should be considered as a novel tumor suppressor gene in prostate cancer.
URI: http://doi.org/10.1007/s13277-014-2703-5
http://hdl.handle.net/11147/5556
ISSN: 1010-4283
1423-0380
1010-4283
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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