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Title: In vitro evaluation of doxorubicin-incorporated magnetic albumin nanospheres
Authors: Zeybek, Ayça
Şanlı Mohamed, Gülşah
Ak, Güliz
Yılmaz, Habibe
Şanlıer, Şenay H.
Keywords: A549 cell line
Magnetic albumin nanoparticle
Targeted drug delivery
Issue Date: Jul-2014
Publisher: John Wiley and Sons Inc.
Source: Zeybek, A., Şanlı Mohamed, G., Ak, G., Yılmaz, H., and Şanlıer, Ş.H. (2014). In vitro evaluation of doxorubicin-incorporated magnetic albumin nanospheres. Chemical Biology and Drug Design, 84(1), 108-115. doi:10.1111/cbdd.12300
Abstract: Magnetic albumin nanospheres that incorporate doxorubicin (M-DOX-BSA-NPs) were prepared previously by our research group to develop magnetically responsive drug carrier system. This nanocarrier was synthesized as a drug delivery system for targeted chemotherapy. In this work, cytotoxic effects of doxorubicin (DOX)-loaded/unloaded or magnetic/non-magnetic nanoparticles and free DOX against PC-3 cells and A549 cells were determined with the MTT test and the results were compared with each other. DOX-loaded magnetic albumin nanospheres (M-DOX-BSA-NPs) were found more cytotoxic than other formulations. The quantitative data obtained from flow cytometry analysis further verified the higher targeting and killing ability of M-DOX-BSA-NPs than free DOX on both of the cancer cell lines. Additionally, the results of cell cycle analysis have showed that M-DOX-BSA-NPs affected G1 and G2 phases. Finally, cell images were obtained using spin-disk confocal microscopy, and cellular uptake of M-DOX-BSA-NPs was visualized. The findings of this study suggest that M-DOX-BSA-NPs represent a potential doxorubicin delivery system for targeted drug transport into prostate and lung cancer cells. In this study, we found that M-DOX-BSA-NPs provide many advantages as targeted drug delivery, enhanced drug killing ability and bioavailability based on cytotoxicity, flow cytometry, and confocal microscopy image results.
ISSN: 1747-0277
Appears in Collections:Chemistry / Kimya
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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