Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5647
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAtik, Ahmet Emin-
dc.contributor.authorHernandez, Oscar-
dc.contributor.authorMaitre, Philippe-
dc.contributor.authorYalçın, Talat-
dc.date.accessioned2017-05-30T13:10:13Z-
dc.date.available2017-05-30T13:10:13Z-
dc.date.issued2014-12-
dc.identifier.citationAtik, A.E., Hernandez, O., Maître, P., and Yalçın, T. (2014). Specific rearrangement reactions of acetylated lysine containing peptide bn (n=4-7) ion series. Journal of Mass Spectrometry, 49(12), 1290-1297. doi:10.1002/jms.3462en_US
dc.identifier.issn1076-5174-
dc.identifier.urihttps://doi.org/10.1002/jms.3462-
dc.identifier.urihttp://hdl.handle.net/11147/5647-
dc.description.abstractCharacterization of ε-N-acetylated lysine containing peptides, one of the most prominent post-translational modifications of proteins, is an important goal for tandem mass spectrometry experiments. A systematic study for the fragmentation reactions of b ions derived from ε-N-acetyllysine containing model octapeptides (KAcYAGFLVG and YAKAcGFLVG) has been examined in detail. Collision-induced dissociation (CID) mass spectra of bn (n=4-7) fragments of ε-N-acetylated lysine containing peptides are compared with those of N-terminal acetylated and doubly acetylated (both ε-N and N-terminal) peptides, as well as acetyl-free peptides. Both direct and nondirect fragments are observed for acetyl-free and singly acetylated (ε-N or N-terminal) peptides. In the case of ε-N-acetylated lysine containing peptides, however, specific fragment ions (m/z 309, 456, 569 and 668) are observed in CID mass spectra of bn (n=4-7) ions. The CID mass spectra of these four ions are shown to be identical to those of selected protonated C-terminal amidated peptides. On this basis, a new type of rearrangement chemistry is proposed to account for the formation of these fragment ions,which are specific for ε-N-acetylated lysine containing peptides. Consistent with the observation of nondirect fragments, it is proposed that the b ions undergo head-to-tail macrocyclization followed by ring opening. The proposed reaction pathway assumes that bn (n=4-7) of ε-N-acetylated lysine containing peptides has a tendency to place the KAc residue at the C-terminal position after macrocyclization/reopening mechanism. Then, following the loss of CO, it is proposed that the marker ions are the result of the loss of an acetyllysine imine as a neutral fragment.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (113Z172); State Planning Organization, DPT; Reseau National de Spectrometrie de Masse FT - ICR a tres haut champ (FR3624)en_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Inc.en_US
dc.relationinfo:eu-repo/grantAgreement/TUBITAK/KBAG/113Z172en_US
dc.relation.ispartofJournal of Mass Spectrometryen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMacrocyclization of b ionsen_US
dc.subjectPeptide fragmentationen_US
dc.subjectLysine acetylationen_US
dc.subjectPeptidesen_US
dc.titleSpecific Rearrangement Reactions of Acetylated Lysine Containing Peptide Bn (n=4-7) Ion Seriesen_US
dc.typeArticleen_US
dc.authoridTR130617en_US
dc.institutionauthorAtik, Ahmet Emin-
dc.institutionauthorYalçın, Talat-
dc.departmentİzmir Institute of Technology. Chemistryen_US
dc.identifier.volume49en_US
dc.identifier.issue12en_US
dc.identifier.startpage1290en_US
dc.identifier.endpage1297en_US
dc.identifier.wosWOS:000345998800012en_US
dc.identifier.scopus2-s2.0-84916207773en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1002/jms.3462-
dc.identifier.pmid25476947en_US
dc.relation.doi10.1002/jms.3462en_US
dc.coverage.doi10.1002/jms.3462en_US
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ2-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept04.01. Department of Chemistry-
Appears in Collections:Chemistry / Kimya
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Files in This Item:
File Description SizeFormat 
5647.pdfMakale1.31 MBAdobe PDFThumbnail
View/Open
Show simple item record



CORE Recommender

SCOPUSTM   
Citations

1
checked on Dec 6, 2024

WEB OF SCIENCETM
Citations

1
checked on Dec 7, 2024

Page view(s)

478
checked on Dec 9, 2024

Download(s)

410
checked on Dec 9, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.