Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5904
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dc.contributor.authorYaşar Mahlıçlı, Filiz-
dc.contributor.authorŞen, Yasin-
dc.contributor.authorMutlu, Mehmet-
dc.contributor.authorAlsoy Altınkaya, Sacide-
dc.date.accessioned2017-07-10T10:58:26Z-
dc.date.available2017-07-10T10:58:26Z-
dc.date.issued2015-04-01-
dc.identifier.citationYaşar Mahlıçlı, F., Şen, Y., Mutlu, M., and Alsoy Altınkaya, S. (2015). Immobilization of superoxide dismutase/catalase onto polysulfone membranes to suppress hemodialysis-induced oxidative stress: A comparison of two immobilization methods. Journal of Membrane Science, 479, 175-189. doi:10.1016/j.memsci.2014.12.025en_US
dc.identifier.issn0376-7388-
dc.identifier.issn1873-3123-
dc.identifier.urihttps://doi.org/10.1016/j.memsci.2014.12.025-
dc.identifier.urihttp://hdl.handle.net/11147/5904-
dc.description.abstractThe objective of this study is to improve the blood compatibility of polysulfone (PSF) based hemodialysis membranes through generating antioxidative surfaces with superoxide dismutase (SOD)/catalase (CAT) enzyme couple immobilization. Enzymes were attached both covalently and ionically on the plasma treated and polyethyleneimine (PEI) deposited membranes, respectively. The loss of enzymes from PEI modified surface at the end of 4 h was found to be relatively higher during storage in phosphate buffered saline (PBS) at pH 7.4 when compared to the enzymes on the plasma treated surface. The kinetic studies indicated that SOD catalyzed the reaction in the diffusion-limited regime at all substrate concentrations and its inactivation by hydrogen peroxide was prevented in the presence of CAT. SOD/CAT coated PSF membranes were capable of reducing the levels of reactive oxygen species in blood and can significantly prolong activated partial thromboplastin time. In addition, both the adsorption of human plasma proteins and platelet activation on all modified membranes decreased significantly compared to the unmodified PSF membranes. Proposed modification methods did not affect high permeability, high mechanical strength or the non-toxic properties of the PSF membranes.en_US
dc.description.sponsorshipL'Oreal Turkey Women in Science Program; Izmir Institute of Technology (2010IYTE03)en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofJournal of Membrane Scienceen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCatalaseen_US
dc.subjectPlasma treatmenten_US
dc.subjectPolysulfone membraneen_US
dc.subjectSuperoxide dismutaseen_US
dc.subjectEnzyme immobilizationen_US
dc.subjectPolyelectrolytesen_US
dc.titleImmobilization of superoxide dismutase/catalase onto polysulfone membranes to suppress hemodialysis-induced oxidative stress: A comparison of two immobilization methodsen_US
dc.typeArticleen_US
dc.authoridTR2091en_US
dc.institutionauthorYaşar Mahlıçlı, Filiz-
dc.institutionauthorAlsoy Altınkaya, Sacide-
dc.departmentİzmir Institute of Technology. Chemical Engineeringen_US
dc.identifier.volume479en_US
dc.identifier.startpage175en_US
dc.identifier.endpage189en_US
dc.identifier.wosWOS:000349620000021en_US
dc.identifier.scopus2-s2.0-84922346657en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.memsci.2014.12.025-
dc.relation.doi10.1016/j.memsci.2014.12.025en_US
dc.coverage.doi10.1016/j.memsci.2014.12.025en_US
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept03.02. Department of Chemical Engineering-
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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