Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5955
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKartal Yandım, Melis-
dc.contributor.authorAdan Gökbulut, Aysun-
dc.contributor.authorBaran, Yusuf-
dc.date.accessioned2017-07-19T07:20:12Z-
dc.date.available2017-07-19T07:20:12Z-
dc.date.issued2016-07-
dc.identifier.citationKartal Yandım, M., Adan Gökbulut, A., and Baran, Y. (2016). Molecular mechanisms of drug resistance and its reversal in cancer. Critical Reviews in Biotechnology, 36(4), 716-726. doi:10.3109/07388551.2015.1015957en_US
dc.identifier.issn0738-8551-
dc.identifier.urihttps://doi.org/10.3109/07388551.2015.1015957-
dc.identifier.urihttp://hdl.handle.net/11147/5955-
dc.description.abstractChemotherapy is the main strategy for the treatment of cancer. However, the main problem limiting the success of chemotherapy is the development of multidrug resistance. The resistance can be intrinsic or acquired. The resistance phenotype is associated with the tumor cells that gain a cross-resistance to a large range of drugs that are structurally and functionally different. Multidrug resistance arises via many unrelated mechanisms, such as overexpression of energy-dependent efflux proteins, decrease in uptake of the agents, increase or alteration in drug targets, modification of cell cycle checkpoints, inactivation of the agents, compartmentalization of the agents, inhibition of apoptosis and aberrant bioactive sphingolipid metabolism. Exact elucidation of resistance mechanisms and molecular and biochemical approaches to overcome multidrug resistance have been a major goal in cancer research. This review comprises the mechanisms guiding multidrug resistance in cancer chemotherapy and also touches on approaches for reversing the resistance.en_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofCritical Reviews in Biotechnologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectABC transportersen_US
dc.subjectApoptosisen_US
dc.subjectBioactive sphingolipidsen_US
dc.subjectCanceren_US
dc.subjectMultidrug resistanceen_US
dc.subjectCell cycle alterationen_US
dc.titleMolecular mechanisms of drug resistance and its reversal in canceren_US
dc.typeArticleen_US
dc.authorid0000-0002-1056-4673en_US
dc.institutionauthorKartal Yandım, Melis-
dc.institutionauthorAdan Gökbulut, Aysun-
dc.institutionauthorBaran, Yusuf-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume36en_US
dc.identifier.issue4en_US
dc.identifier.startpage716en_US
dc.identifier.endpage726en_US
dc.identifier.wosWOS:000381053900012en_US
dc.identifier.scopus2-s2.0-84942314013en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.3109/07388551.2015.1015957-
dc.identifier.pmid25757878en_US
dc.relation.doi10.3109/07388551.2015.1015957en_US
dc.coverage.doi10.3109/07388551.2015.1015957en_US
dc.identifier.scopusqualityQ1-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Files in This Item:
File Description SizeFormat 
5955.pdfMakale314.92 kBAdobe PDFThumbnail
View/Open
Show simple item record




CORE Recommender

SCOPUSTM   
Citations

214
checked on May 27, 2023

WEB OF SCIENCETM
Citations

200
checked on May 27, 2023

Page view(s)

172
checked on May 22, 2023

Download(s)

840
checked on May 22, 2023

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.