Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5998
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dc.contributor.authorBor, Gizem-
dc.contributor.authorÜçüncü, Muhammed-
dc.contributor.authorEmrullahoğlu, Mustafa-
dc.contributor.authorTomak, Aysel-
dc.contributor.authorŞanlı Mohamed, Gülşah-
dc.date.accessioned2017-07-24T07:52:43Z
dc.date.available2017-07-24T07:52:43Z
dc.date.issued2017-10
dc.identifier.citationBor, G., Üçüncü, M., Emrullahoǧlu, M., Tomak, A., and Şanlı Mohamed, G. (2016). BODIPY-conjugated chitosan nanoparticles as a fluorescent probe. Drug and Chemical Toxicology. doi:10.1080/01480545.2016.1238481en_US
dc.identifier.issn0148-0545
dc.identifier.issn0148-0545-
dc.identifier.urihttp://doi.org/10.1080/01480545.2016.1238481
dc.identifier.urihttp://hdl.handle.net/11147/5998
dc.description.abstractRecently, development of fluorescent nanoparticle-based probes for various bioimaging applications has attracted great attention. This work aims to develop a new type fluorescent nanoparticle conjugate and evaluate its cytotoxic effects on A549 and BEAS 2B cell lines. Throughout the study, ionically crosslinked chitosan nanoparticles (CNs) were conjugated with carboxylated 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY-COOH). The results of conjugates (BODIPY-CNs) were investigated with regard to their physic-chemical, optical, cytotoxic properties and cellular internalization. The morphology of BODIPY-CNs was found to be spherical in shape and quite uniform having average diameter of 70.25 ± 11.99 nm. Cytotoxicty studies indicated that although BODIPY-COOH itself was quite toxic on both A549- and BEAS 2B-treated cells, CNs increased the cell viability of both cell lines via conjugation to BODIPY-COOH fluorescent molecule up to 67% for A549 and 74% for BEAS 2B cells. These results may suggest a possible utilization of the new fluorescent nanoparticle-based probe for bioimaging in biology and medicine.en_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectA549 cellsen_US
dc.subjectBEAS 2B cellsen_US
dc.subjectBODIPYen_US
dc.subjectChitosanen_US
dc.subjectCytotoxicityen_US
dc.titleBODIPY-conjugated chitosan nanoparticles as a fluorescent probeen_US
dc.typeArticleen_US
dc.authoridTR203331en_US
dc.authoridTR115002en_US
dc.institutionauthorBor, Gizem-
dc.institutionauthorÜçüncü, Muhammed-
dc.institutionauthorEmrullahoğlu, Mustafa-
dc.institutionauthorTomak, Aysel-
dc.institutionauthorŞanlı Mohamed, Gülşah-
dc.departmentİzmir Institute of Technology. Chemistryen_US
dc.departmentİzmir Institute of Technology. Materials Science and Engineeringen_US
dc.identifier.volume40en_US
dc.identifier.issue4
dc.identifier.startpage375en_US
dc.identifier.endpage382en_US
dc.identifier.wosWOS:000406544200001en_US
dc.identifier.scopus2-s2.0-84996490411en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1080/01480545.2016.1238481-
dc.identifier.pmid27866417en_US
dc.relation.doi10.1080/01480545.2016.1238481en_US
dc.coverage.doi10.1080/01480545.2016.1238481en_US
local.message.claim2022-06-08T11:06:46.370+0300|||rp00482|||submit_approve|||dc_contributor_author|||None*
dc.identifier.wosqualityQ3-
dc.identifier.scopusqualityQ2-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.openairetypeArticle-
item.cerifentitytypePublications-
crisitem.author.dept04.04. Department of Photonics-
crisitem.author.dept03.01. Department of Bioengineering-
crisitem.author.dept04.01. Department of Chemistry-
Appears in Collections:Chemistry / Kimya
Materials Science and Engineering / Malzeme Bilimi ve Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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