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Title: Major apoptotic mechanisms and genes involved in apoptosis
Authors: Kiraz, Yağmur
Adan, Aysun
Kartal Yandım, Melis
Baran, Yusuf
Keywords: Caspase
Protein bcl 2
Protein p53
Tumor necrosis factor
Issue Date: Jul-2016
Publisher: SAGE Publications
Source: Kiraz, Y., Adan, A., Kartal Yandım, M., and Baran, Y. (2016). Major apoptotic mechanisms and genes involved in apoptosis. Tumor Biology, 37(7), 8471-8486. doi:10.1007/s13277-016-5035-9
Abstract: As much as the cellular viability is important for the living organisms, the elimination of unnecessary or damaged cells has the opposite necessity for the maintenance of homeostasis in tissues, organs and the whole organism. Apoptosis, a type of cell death mechanism, is controlled by the interactions between several molecules and responsible for the elimination of unwanted cells from the body. Apoptosis can be triggered by intrinsically or extrinsically through death signals from the outside of the cell. Any abnormality in apoptosis process can cause various types of diseases from cancer to auto-immune diseases. Different gene families such as caspases, inhibitor of apoptosis proteins, B cell lymphoma (Bcl)-2 family of genes, tumor necrosis factor (TNF) receptor gene superfamily, or p53 gene are involved and/or collaborate in the process of apoptosis. In this review, we discuss the basic features of apoptosis and have focused on the gene families playing critical roles, activation/inactivation mechanisms, upstream/downstream effectors, and signaling pathways in apoptosis on the basis of cancer studies. In addition, novel apoptotic players such as miRNAs and sphingolipid family members in various kind of cancer are discussed.
ISSN: 1423-0380
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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