Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/6287
Title: Mice with catalytically inactive Cathepsin A display neurobehavioral alterations
Authors: Çalhan, Osman Yipkin
Seyrantepe, Volkan
Keywords: Cathepsin A
lysosome enzyme
Oxytocin
Endothelin
Carboxypeptidase
Issue Date: 2017
Publisher: Hindawi Publishing Corporation
Source: Çalhan, O. Y., and Seyrantepe, V. (2017). Mice with catalytically inactive Cathepsin A display neurobehavioral alterations. Behavioural Neurology, 2017. doi:10.1155/2017/4261873
Abstract: The lysosomal carboxypeptidase A, Cathepsin A (CathA), is a serine protease with two distinct functions. CathA protects β-galactosidase and sialidase Neu1 against proteolytic degradation by forming a multienzyme complex and activates sialidase Neu1. CathA deficiency causes the lysosomal storage disease, galactosialidosis. These patients present with a broad range of clinical phenotypes, including growth retardation, and neurological deterioration along with the accumulation of the vasoactive peptide, endothelin-1, in the brain. Previous in vitro studies have shown that CathA has specific activity against vasoactive peptides and neuropeptides, including endothelin-1 and oxytocin. A mutant mouse with catalytically inactive CathA enzyme (CathAS190A) shows increased levels of endothelin-1. In the present study, we elucidated the involvement of CathA in learning and long-term memory in 3-, 6-, and 12-month-old mice. Hippocampal endothelin-1 and oxytocin accumulated in CathAS190A mice, which showed learning impairments as well as long-term and spatial memory deficits compared with wild-type littermates, suggesting that CathA plays a significant role in learning and in memory consolidation through its regulatory role in vasoactive peptide processing.
URI: http://doi.org/10.1155/2017/4261873
http://hdl.handle.net/11147/6287
ISSN: 0953-4180
1875-8584
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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