Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/6631
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dc.contributor.authorAslanipour, Behnaz-
dc.contributor.authorGülcemal, Derya-
dc.contributor.authorNalbantsoy, Ayşe-
dc.contributor.authorYusufoğlu, Hasan-
dc.contributor.authorBedir, Erdal-
dc.date.accessioned2018-01-02T13:31:19Z-
dc.date.available2018-01-02T13:31:19Z-
dc.date.issued2017-09-
dc.identifier.citationAslanipour, B., Gülcemal, D., Nalbantsoy, A., Yusufoğlu, H., and Bedir, E. (2017). Cycloartane-type glycosides from Astragalus brachycalyx FISCHER and their effects on cytokine release and hemolysis. Phytochemistry Letters, 21, 66-73. doi:10.1016/j.phytol.2017.05.028en_US
dc.identifier.issn1876-7486-
dc.identifier.issn1874-3900-
dc.identifier.urihttp://doi.org/10.1016/j.phytol.2017.05.028-
dc.identifier.urihttp://hdl.handle.net/11147/6631-
dc.description.abstractTwo new tridesmosidic cycloartane-type triterpene glycosides (1 and 2) were isolated from the methanolic extract of the roots of Astragalus brachycalyx FISCHER (A. brachycalyx) along with ten (3–12) known cycloartane-type triterpene glycosides. Structures of the new compounds were established as 3-O-β-D-xylopyranosyl-6-O-β-D-glucopyranosyl-16-O-β-D-glucopyranosyl-3β,6α,16β,24(S)-25-pentahydroxycycloartane (1), 3-O-[α-L-arabinopyranosyl-(1→2)-β-D-xylopyranosyl]-6-O-β-D-glucopyranosyl-16-O-β-D-glucopyranosyl-3β,6α,16β,24(S)-25-pentahydroxycycloartane (2), by using 1D and 2D-NMR techniques and mass spectrometry. In vitro immunomodulatory effects and hemolytic activities of the new saponins (1 and 2) and acetylated form of 1 (1a) were studied together with the BuOH and MeOH extracts of Astragalus brachycalyx. The results have proven that tridesmosidic Astragalus cycloartanes are noteworthy immunomodulatory compounds via induction of cytokine production, namely IL-2 and IFN-γ. The test compounds also resulted slight hemolysis at very high doses substantiating a safer profile compared to the positive control QS-21.en_US
dc.description.sponsorshipEge University Research Foundation (15-FBE-001)en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofPhytochemistry Lettersen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAstragalus brachycalyxen_US
dc.subjectFabaceaeen_US
dc.subjectSaponinsen_US
dc.subjectCycloartaneen_US
dc.subjectCytokine stimulationen_US
dc.titleCycloartane-type glycosides from Astragalus brachycalyx FISCHER and their effects on cytokine release and hemolysisen_US
dc.typeArticleen_US
dc.authoridTR12161en_US
dc.institutionauthorBedir, Erdal-
dc.institutionauthorBedir, Erdal-
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.volume21en_US
dc.identifier.startpage66en_US
dc.identifier.endpage73en_US
dc.identifier.wosWOS:000414229300014en_US
dc.identifier.scopus2-s2.0-85020619227en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.phytol.2017.05.028-
dc.relation.doi10.1016/j.phytol.2017.05.028en_US
dc.coverage.doi10.1016/j.phytol.2017.05.028en_US
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ1-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.openairetypeArticle-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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