Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/6653
Title: Diatomite reinforced chitosan composite membrane as potential scaffold for guided bone regeneration
Authors: Tamburacı, Sedef
Tıhmınlıoğlu, Funda
Tamburacı, Sedef
Tıhmınlıoğlu, Funda
Keywords: Membrane
Biomaterials
Natural silica
Diatomite
Bone
Composite materials
Issue Date: Nov-2017
Publisher: Elsevier Ltd.
Source: Tamburacı, S., and Tıhmınlıoğlu, F. (2017). Diatomite reinforced chitosan composite membrane as potential scaffold for guided bone regeneration. Materials Science and Engineering C, 80, 222-231. doi:10.1016/j.msec.2017.05.069
Abstract: In this study, natural silica source, diatomite, incorporated novel chitosan based composite membranes were fabricated and characterized for bone tissue engineering applications as possible bone regeneration membrane. The effect of diatomite loading on the mechanical, morphological, chemical, thermal and surface properties, wettability and in vitro cytotoxicity and cell proliferation on of composite membranes were investigated and observed by tensile test, atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), protein adsorption assay, air/water contact angle analysis and WST-1 respectively. Swelling studies were also performed by water absorption capacity determination. Results showed that incorporation of diatomite to the chitosan matrix increased the surface roughness, swelling capacity and tensile modulus of membranes. An increase of about 52% in Young's modulus was achieved for 10 wt% diatomite composite membranes compared with chitosan membranes. High cell viability results were obtained with indirect extraction method. Besides, in vitro cell proliferation and ALP activity results showed that diatom incorporation significantly increased the ALP activity of Saos-2 cells cultured on chitosan membranes. The novel composite membranes prepared in the present study with tunable properties can be considered as a potential candidate as a scaffold in view of its enhanced physical & chemical properties as well as biological activities for bone tissue engineering applications.
URI: http://doi.org/10.1016/j.msec.2017.05.069
http://hdl.handle.net/11147/6653
ISSN: 0928-4931
1873-0191
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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