Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/6818
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dc.contributor.authorYousef, Malik-
dc.contributor.authorTrinh, Hung V.-
dc.contributor.authorAllmer, Jens-
dc.date.accessioned2018-02-21T08:29:47Z-
dc.date.available2018-02-21T08:29:47Z-
dc.date.issued2014-09-
dc.identifier.citationYousef, M., Trinh, H. V., and Allmer, J. (2014). Intersection of MicroRNA and gene regulatory networks and their implication in cancer. Current Pharmaceutical Biotechnology, 15(5), 445-454. doi:10.2174/1389201015666140519120855en_US
dc.identifier.issn1389-2010-
dc.identifier.urihttp://doi.org/10.2174/1389201015666140519120855-
dc.identifier.urihttp://hdl.handle.net/11147/6818-
dc.description.abstractMicroRNAs (miRNAs) have attracted heightened attention for their role as post-transcriptional regulators of gene expression. It has become clear that miRNAs can both up- and downregulate protein expression. According to current estimates, most human genes are harboring miRNAs and/or are regulated by them. Thus miRNAs form a complex network of expression regulation which tightly interacts with known gene regulatory networks. Similar to some transcription factors, some miRNAs can have hundreds of target transcripts whose expression they modulate. Thus miRNAs can form complex regulatory networks by themselves, but because their expression is often tightly coordinated with gene expression, they form an intertwined regulatory network with many possible interactions among gene and miRNA regulatory pathways. In this review we first consider gene regulatory networks. Then we discuss microRNAs and their implication in cancer and how they may form regulatory networks. Finally, we give our perspective and provide an outlook including the aspect of personalized medicine.en_US
dc.description.sponsorshipTurkish Academy of Sciences (GEBIP, TUBA); Swiss National Science Foundation (SNSF / PBZHP3_141430); Swiss Foundation for Medical-Biological (SFGBM P3SMP3_148406)en_US
dc.language.isoenen_US
dc.publisherBentham Science Publishers B.V.en_US
dc.relation.ispartofCurrent Pharmaceutical Biotechnologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMicroRNAsen_US
dc.subjectMetastasisen_US
dc.subjectReconstructionen_US
dc.subjectTumor suppressionen_US
dc.subjectPetri netsen_US
dc.titleIntersection of MicroRNA and gene regulatory networks and their implication in canceren_US
dc.typeArticleen_US
dc.authoridTR107974en_US
dc.institutionauthorAllmer, Jens-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume15en_US
dc.identifier.issue5en_US
dc.identifier.startpage445en_US
dc.identifier.endpage454en_US
dc.identifier.wosWOS:000341916200004en_US
dc.identifier.scopus2-s2.0-84907165143en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.2174/1389201015666140519120855-
dc.identifier.pmid24846065en_US
dc.relation.doi10.2174/1389201015666140519120855en_US
dc.coverage.doi10.2174/1389201015666140519120855en_US
dc.identifier.wosqualityQ3-
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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