Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/6843
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dc.contributor.authorBatı Ayaz, Gizem-
dc.contributor.authorCan, Ali-
dc.contributor.authorPesen Okvur, Devrim-
dc.date.accessioned2018-03-27T11:27:20Z-
dc.date.available2018-03-27T11:27:20Z-
dc.date.issued2017-10-
dc.identifier.citationBatı Ayaz, G., Can, A., and Pesen Okvur, D (2017). Cellular distribution of invadopodia is regulated by nanometer scale surface protein patterns. European Journal of Cell Biology, 96(7), 673-684. doi:10.1016/j.ejcb.2017.08.001en_US
dc.identifier.issn0171-9335-
dc.identifier.issn1618-1298-
dc.identifier.urihttps://doi.org/10.1016/j.ejcb.2017.08.001-
dc.identifier.urihttp://hdl.handle.net/11147/6843-
dc.description.abstractInvadopodia are proteolytic structures formed by cancer cells. It is not known whether their cellular distribution can be regulated by the organization of the extracellular matrix or the organization of the golgi complex or whether they have an adhesion requirement. Here, we used electron beam lithography to fabricate fibronectin (FN) nanodots with isotropic and gradient micrometer scale spacings on K-casein and laminin backgrounds. Investigating cancer cells cultured on protein nanopatterns, we showed that (i) presence of FN nanodots on a K-casein background decreased percent of cells with neutral invadopodia polarization compared to FN control surfaces; (ii) presence of a gradient of FN nanodots on a K-casein background increased percent of cells with negative invadopodia polarization compared to FN control surfaces; (iii) polarization of the golgi complex was similar to that of invadopodia in agreement with a spatial link; (iv) local adhesion did not necessarily appear to be a prerequisite for invadopodia formation.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK 111T547) State Planning Organization (DPT 2009K120860)en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relationinfo:eu-repo/grantAgreement/TUBITAK/TBAG/111T547en_US
dc.relation.ispartofEuropean Journal of Cell Biologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectElectron beam lithographyen_US
dc.subjectNanopatternen_US
dc.subjectInvadopodiaen_US
dc.subjectCortactinen_US
dc.subjectGolgi complexen_US
dc.titleCellular distribution of invadopodia is regulated by nanometer scale surface protein patternsen_US
dc.typeArticleen_US
dc.authoridTR114932en_US
dc.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume96en_US
dc.identifier.issue7en_US
dc.identifier.startpage673en_US
dc.identifier.endpage684en_US
dc.identifier.wosWOS:000413611300004
dc.identifier.scopusSCOPUS:2-s2.0-85028351297
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.ejcb.2017.08.001-
dc.relation.doi10.1016/j.ejcb.2017.08.001en_US
dc.coverage.doi10.1016/j.ejcb.2017.08.001en_US
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.deptDepartment of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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