Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7529
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dc.contributor.authorYılmaz, Gökhan-
dc.contributor.authorGüler, Emine-
dc.contributor.authorGeyik, Caner-
dc.contributor.authorDemir, Bilal-
dc.contributor.authorÖzkan, Melek-
dc.contributor.authorOdacı Demirkol, Dilek-
dc.contributor.authorÖzçelik, Serdar-
dc.contributor.authorTimur, Suna-
dc.contributor.authorBecer, C. Remzi-
dc.date.accessioned2019-12-26T07:18:49Z
dc.date.available2019-12-26T07:18:49Z
dc.date.issued2018-02en_US
dc.identifier.citationYılmaz, G., Güler, E., Geyik, C., Demir, B., Özkan, M., Odacı Demirkol, D., Özçelik, S., Timur, S., and Becer, C. R. (2018). pH responsive glycopolymer nanoparticles for targeted delivery of anti-cancer drugs. Molecular Systems Design and Engineering, 3(1), 150-158. doi:10.1039/c7me00086cen_US
dc.identifier.issn2058-9689
dc.identifier.issn2058-9689-
dc.identifier.urihttps://doi.org/10.1039/c7me00086c
dc.identifier.urihttps://hdl.handle.net/11147/7529
dc.description.abstractOver the past decade, there has been a great deal of interest in the integration of nanotechnology and carbohydrates. The advances in glyconanotechnology have allowed the creation of different bioactive glyconanostructures for different types of medical applications, especially for drug delivery and release systems. Therefore, the use of more efficient biocompatible nanocarriers with high loading capacity, low overall toxicity and receptor-mediated endocytosis specificity is still in focus for the enhancement of the therapeutic effect. Conjugation of sugar derivatives onto gold nanoparticles presents unique properties that include a wide array of assembling models and size-related electronic, magnetic and optical properties. Here, pH-responsive drug-conjugated glycopolymer-coated gold nanoparticles were prepared by functionalization of gold nanoparticles with thiol-terminated glycopolymers and then subsequent conjugation of doxorubicin (DOX). Among the four different glycopolymers, their drug release, physicochemical characterization (spectroscopy, particle size and surface charge) and in vitro bioapplications with four different cell lines were compared. As a result, pH-sensitive drug delivery via sugar-coated AuNPs was performed thanks to hydrazone linkages between glycopolymers and DOX. Comparative viability tests also demonstrated the efficiency of glycopolymer-DOX conjugates by fluorescence cell imaging. The obtained results reveal that AuNP homoglycopolymer DOX conjugates (P4D) have significant potential, especially in human neuroblastoma cells in comparison to cervical cancer cells and lung cancer cells.en_US
dc.description.sponsorshipEngineering & Physical Sciences Research Council (EPSRC) EP/P009018/1en_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.ispartofMolecular Systems Design and Engineeringen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDrug delivery systemsen_US
dc.subjectDoxorubicinen_US
dc.subjectCancer drugsen_US
dc.subjectGold nanoparticleen_US
dc.subjectGlycopolymersen_US
dc.titlepH responsive glycopolymer nanoparticles for targeted delivery of anti-cancer drugsen_US
dc.typeArticleen_US
dc.institutionauthorÖzçelik, Serdar-
dc.departmentİzmir Institute of Technology. Chemistryen_US
dc.identifier.volume3en_US
dc.identifier.issue1en_US
dc.identifier.startpage150en_US
dc.identifier.endpage158en_US
dc.identifier.wosWOS:000424988400014en_US
dc.identifier.scopus2-s2.0-85042007888en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1039/c7me00086c-
dc.relation.doi10.1039/c7me00086cen_US
dc.coverage.doi10.1039/c7me00086cen_US
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ1-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairetypeArticle-
crisitem.author.dept04.01. Department of Chemistry-
Appears in Collections:Chemistry / Kimya
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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