Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7584
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dc.contributor.authorPehlivan, Melek-
dc.contributor.authorÇalışkan, Ceyda-
dc.contributor.authorYüce, Zeynep-
dc.contributor.authorSercan, Hakkı Ogün-
dc.date.accessioned2020-01-15T11:16:10Z-
dc.date.available2020-01-15T11:16:10Z-
dc.date.issued2018-06en_US
dc.identifier.citationPehlivan, M., Çalışkan, C., Yüce, Z., and Sercan, H. O. (2018). Secreted Wnt antagonists in leukemia: A road yet to be paved. Leukemia Research, 69, 24-30. doi:10.1016/j.leukres.2018.03.011en_US
dc.identifier.issn0145-2126-
dc.identifier.issn0145-2126-
dc.identifier.urihttps://doi.org/10.1016/j.leukres.2018.03.011-
dc.identifier.urihttps://hdl.handle.net/11147/7584-
dc.description.abstractWnt signaling has been a topic of research for many years for its diverse and fundamental functions in physiological (such as embryogenesis, organogenesis, proliferation, tissue repair and cellular differentiation) and pathological (carcinogenesis, congenital/genetic diseases, and tissue degeneration) processes. Wnt signaling pathway aberrations are associated with both solid tumors and hematological malignancies. Unregulated Wnt signaling observed in malignancies may be due to a wide spectrum of abnormalities, from mutations in the genes of key players to epigenetic modifications of Wnt antagonists. Of these, Wnt antagonists are gaining significant attention for their potential of being targets for treatment and inhibition of Wnt signaling. In this review, we discuss and summarize the significance of Wnt signaling antagonists in the pathogenesis and treatment of hematological malignancies.en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofLeukemia Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectWnt signaling pathwayen_US
dc.subjectCMLen_US
dc.subjectSecreted Wnt antagonistsen_US
dc.subjectWnt proteinen_US
dc.subjectHematologic malignancyen_US
dc.titleSecreted Wnt antagonists in leukemia: A road yet to be paveden_US
dc.typeArticleen_US
dc.institutionauthorÇalışkan, Ceyda-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume69en_US
dc.identifier.startpage24en_US
dc.identifier.endpage30en_US
dc.identifier.wosWOS:000436483100005en_US
dc.identifier.scopus2-s2.0-85044711345en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.leukres.2018.03.011-
dc.identifier.pmid29625321en_US
dc.relation.doi10.1016/j.leukres.2018.03.011en_US
dc.coverage.doi10.1016/j.leukres.2018.03.011en_US
dc.identifier.wosqualityQ3-
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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