Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7643
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTamburacı, Sedef-
dc.contributor.authorTıhmınlıoğlu, Funda-
dc.date.accessioned2020-01-29T12:10:39Z
dc.date.available2020-01-29T12:10:39Z
dc.date.issued2018-10en_US
dc.identifier.citationTamburacı, S., and Tıhmınlıoğlu, F. (2018). Biosilica incorporated 3D porous scaffolds for bone tissue engineering applications. Materials Science and Engineering C, 91, 274-291. doi:10.1016/j.msec.2018.05.040en_US
dc.identifier.issn0928-4931
dc.identifier.issn0928-4931-
dc.identifier.issn1873-0191-
dc.identifier.urihttps://doi.org/10.1016/j.msec.2018.05.040
dc.identifier.urihttps://hdl.handle.net/11147/7643
dc.description.abstractAs a natural and abundant silica mineral, diatomite particles (SiO2-nH2O) have been used in several areas such as filtration, photonics, sound and heat insulation, filler material and drug delivery due to its abundance, inexpensive cost, unique morphology and porous structure. But up to date, diatomite incorporated silica based scaffolds have not been used for bone tissue engineering applications. In the present study, the goal was to combine the useful biomaterial properties of both chitosan and diatomite as biocomposite organic/inorganic biomaterial for bone tissue engineering applications and optimize the silica content of the composites in order to obtain optimum morphological structure, high mechanical properties, enlarged surface area and enhanced cell proliferation. The effect of silica loading on the mechanical, morphological, chemical, and surface properties, wettability and biocompatibility of composite scaffolds were investigated. In addition, in vitro cytotoxicity and cellular activities including cell proliferation, ALP activity and biomineralization were investigated in order to determine biological activity of the composite scaffolds. Diatomite particles lead to enhancement in the water uptake capacity of scaffolds. Chitosan-silica composites exhibited 82–90% porosity. Wet chitosan-silica composite scaffolds exhibited higher compression moduli when compared to pure chitosan scaffold in the range of 67.3–90.1 kPa. Average pore size range of chitosan-diatomite composite scaffolds was obtained as 218-319 μm. In vitro results indicated that chitosan-diatomite composites did not show any cytotoxic effect on 3T3, MG-63 and Saos-2 cell lines. Scaffolds were found to be favorable for osteoblast proliferation. Diatomite incorporation showed promising effects on enhancing ALP activity as well as mineral formation on scaffold surface. Thus, the prepared scaffolds in this study can be considered prospective material for bone tissue engineering applications.en_US
dc.description.sponsorshipMinistry of Science, Industry & Technology - Turkey 0494.STZ.2013-2en_US
dc.language.isoengen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofMaterials Science and Engineering Cen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectScaffoldsen_US
dc.subjectSilicaen_US
dc.subjectChitosanen_US
dc.subjectBoneen_US
dc.subjectDiatomiteen_US
dc.subjectCell engineeringen_US
dc.subjectBone tissue engineeringen_US
dc.titleBiosilica incorporated 3D porous scaffolds for bone tissue engineering applicationsen_US
dc.typeArticleen_US
dc.authorid0000-0002-3715-8253en_US
dc.institutionauthorTamburacı, Sedef-
dc.institutionauthorTıhmınlıoğlu, Funda-
dc.departmentIzmir Institute of Technology. Chemical Engineeringen_US
dc.identifier.volume91en_US
dc.identifier.startpage274en_US
dc.identifier.endpage291en_US
dc.identifier.wosWOS:000442192000028en_US
dc.identifier.scopus2-s2.0-85047122158en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.msec.2018.05.040-
dc.identifier.pmid30033256en_US
dc.relation.doi10.1016/j.msec.2018.05.040en_US
dc.coverage.doi10.1016/j.msec.2018.05.040en_US
dc.identifier.scopusqualityQ1-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
crisitem.author.dept03.02. Department of Chemical Engineering-
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Files in This Item:
File Description SizeFormat 
1-s2.0-S0928493117336299-main.pdfMakale (Article)10.91 MBAdobe PDFThumbnail
View/Open
Show simple item record

CORE Recommender

SCOPUSTM   
Citations

18
checked on Dec 3, 2022

WEB OF SCIENCETM
Citations

33
checked on Dec 3, 2022

Page view(s)

2,962
checked on Dec 5, 2022

Download(s)

288
checked on Dec 5, 2022

Google ScholarTM

Check

Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.