Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7810
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dc.contributor.authorPolat, Hürriyettr
dc.contributor.authorKutluay, Gülistantr
dc.contributor.authorPolat, Mehmettr
dc.date.accessioned2020-07-18T03:35:10Z-
dc.date.available2020-07-18T03:35:10Z-
dc.date.issued2020-
dc.identifier.issn0927-7757-
dc.identifier.urihttps://doi.org/10.1016/j.colsurfa.2020.124989-
dc.identifier.urihttps://hdl.handle.net/11147/7810-
dc.description.abstractMicelles of self-assembling polymeric surfactant molecules are promising nanoscopic carriers for lipophilic and toxic drugs, genes, and imaging molecules. Though it is a must for successful transport, ensuring micelle integrity is a challenge during intravenous injection where micelles must endure abrupt dilutional effects and encounters with native molecules. Therefore, direct observational evidence of how micelles behave during dilution is valuable in manipulating the designs of these carriers for a succesful drug delivery. Morphology and stability of the barren and a drug-loaded (lipophilic probucol) micelles of a polymeric surfactant (Pluronic® P123) were monitored during systematic re-dilution in distilled water and simulated body fluid in the presence of a model protein (bovine serum albumin). It was observed through surface tension, dynamic light scattering, laser velocimetry, transmission scanning and transmission electron microscopy, and atomic force microscopy analyses that the micelles disintegrated to various degrees in all cases upon dilution. The results indicate that dilution effects must be taken into account in designing micellar drug carriers. The assistance of some other means of protection such as encapsulation should be considered for ensuring micelle integrity within the bloodstream. © 2020 Elsevier B.V.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofColloids and Surfaces A: Physicochemical and Engineering Aspectsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDrug carrieren_US
dc.subjectMicellesen_US
dc.subjectPolymeric surfactanten_US
dc.subjectProteinen_US
dc.subjectStabilityen_US
dc.titleAnalysis of dilution induced disintegration of micellar drug carriers in the presence of inter and intra micellar speciesen_US
dc.typeArticleen_US
dc.institutionauthorPolat, Hürriyettr
dc.institutionauthorKutluay, Gülistantr
dc.institutionauthorPolat, Mehmettr
dc.departmentİzmir Institute of Technology. Chemical Engineeringen_US
dc.departmentİzmir Institute of Technology. Chemistryen_US
dc.identifier.volume601en_US
dc.identifier.wosWOS:000555701100001en_US
dc.identifier.scopus2-s2.0-85085654511en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr
dc.identifier.doi10.1016/j.colsurfa.2020.124989-
dc.relation.doi10.1016/j.colsurfa.2020.124989en_US
dc.coverage.doi10.1016/j.colsurfa.2020.124989en_US
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ2-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.openairetypeArticle-
crisitem.author.dept04.01. Department of Chemistry-
crisitem.author.dept03.02. Department of Chemical Engineering-
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
Chemistry / Kimya
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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