Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7841
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dc.contributor.authorYılmaz, Esra-
dc.contributor.authorÖzçivici, Engin-
dc.contributor.authorTekin, Hüseyin Cumhur-
dc.date.accessioned2020-07-18T03:35:15Z-
dc.date.available2020-07-18T03:35:15Z-
dc.date.issued2019-
dc.identifier.isbn9781728128689-
dc.identifier.urihttps://doi.org/10.1109/ASYU48272.2019.8946406-
dc.identifier.urihttps://hdl.handle.net/11147/7841-
dc.description2019 Innovations in Intelligent Systems and Applications Conference, ASYU 2019 -- 31 October 2019 through 2 November 2019en_US
dc.description.abstractCirculating Tumor Cells (CTCs) play a vital role in cancer diagnosis, prognosis and personalized medicine. However, CTCs are extremely rare in blood (i.e., down to 1-100 CTC per 1 mL human blood) and hard to isolate because of the heterogeneity of CTCs in biomarker expression. The current CTC separation and identification techniques use numerous differences between cells such as size, electric charges, density and expression of cell surface markers. However, these techniques have many limitations in terms of laborious sample preparation steps, inconsistent results caused by low specificity and efficiency and high cost. Hence, there is no standard method for isolating CTCs yet. With this study, it was aimed to fill the gap in CTC isolation and identification by proposing to develop a new method based on magnetic levitation principle, which has recently been demonstrated as a highly acceptable method for biological characterization of cells and monitoring of their cellular events. In this study, we have developed a new label-free microfluidic sorter to separate microparticles/cells based on their densities using magnetic levitation principle. Two different density microparticles (1.02 g/mL and 1.09 g/ mL) have been sorted and quantified in a continuous flow using a set of permanent magnets located in a 3D printed structure surrounding the microfluidic channel. This device can be used for rapid, low cost and label-free in-vitro diagnosis of cancer by sorting CTCs from whole blood in a high-Throughput manner. The sorted cells might further be used for downstream analysis for personalized and precision medicine. © 2019 IEEE.en_US
dc.language.isoenen_US
dc.publisherInstitute of Electrical and Electronics Engineers Inc.en_US
dc.relation.ispartof2019 Innovations in Intelligent Systems and Applications Conference, ASYU 2019en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCell sortingen_US
dc.subjectDensity-based measurementen_US
dc.subjectMagnetic levitationen_US
dc.subjectMicrofluidicsen_US
dc.titleMicrofluidic platform for sorting materials based on their densities using magnetic levitationen_US
dc.typeConference Objecten_US
dc.institutionauthorYılmaz, Esra-
dc.institutionauthorÖzçivici, Engin-
dc.institutionauthorTekin, Hüseyin Cumhur-
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.wosWOS:000631252400056en_US
dc.identifier.scopus2-s2.0-85078335933en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1109/ASYU48272.2019.8946406-
dc.relation.doi10.1109/ASYU48272.2019.8946406en_US
dc.coverage.doi10.1109/ASYU48272.2019.8946406en_US
item.openairetypeConference Object-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept03.01. Department of Bioengineering-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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