Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7918
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dc.contributor.authorSaçar Demirci, Müşerref Duygutr
dc.contributor.authorBağcı, Canertr
dc.contributor.authorAllmer, Jens-
dc.date.accessioned2020-07-18T03:35:23Z-
dc.date.available2020-07-18T03:35:23Z-
dc.date.issued2016-
dc.identifier.isbn9783319394961-
dc.identifier.urihttps://doi.org/10.1007/978-3-319-39496-1_9-
dc.identifier.urihttps://hdl.handle.net/11147/7918-
dc.description.abstractMicroRNAs are short RNA sequences involved in post-transcriptional gene regulation. MicroRNAs are known for a wide variety of species ranging from bacteria to plants. It has become clear that some cross-kingdom regulation is possible especially between viruses and their hosts. We hypothesized that intracellular parasites, like Toxoplasma gondii, similar to viruses would be able to modulate their host’s gene expression. We were able to show that T. gondii produces many putative pre-miRNAs which are actually transcribed. Furthermore, some of these expressed pre-miRNAs have a striking resemblance to host mature miRNAs. Previous studies indicated that T. gondii infection coincides with increased abundance of some miRNAs. Here we were able to show that many of these miRNAs have close relatives in T. gondii which may not be distinguishable using PCR. Taken together, the similarity to host miRNAs, their confirmed expression, and their upregulation during infection, it suggests that T. gondii actively transfers miRNAs to regulate its host. We conclude, that this type of cross-kingdom regulation may be possible, but that targeted analysis is necessary to consolidate our computational findings. © Springer International Publishing Switzerland 2016. All rights are reserved.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNon-coding RNAs and Inter-kingdom Communicationen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleDifferential expression of toxoplasma gondii microRNAs in murine and human hostsen_US
dc.typeBook Parten_US
dc.institutionauthorSaçar Demirci, Müşerref Duygu-
dc.institutionauthorBağcı, Canertr
dc.institutionauthorAllmer, Jens-
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.startpage143en_US
dc.identifier.endpage159en_US
dc.identifier.scopus2-s2.0-85006380470en_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıtr
dc.identifier.doi10.1007/978-3-319-39496-1_9-
dc.relation.doi10.1007/978-3-319-39496-1_9en_US
dc.coverage.doi10.1007/978-3-319-39496-1_9en_US
item.openairetypeBook Part-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Bioengineering / Biyomühendislik
Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
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