Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/8881
Title: Fish scale/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanofibrous composite scaffolds for bone regeneration
Authors: Kara, Aylin
Güneş, Oylum C.
Albayrak, Aylin Z.
Bilici, Gökçen
Erbil, Güven
Havitcioğlu, Hasan
Keywords: Fish scale
Scaffold
PHBV
Electrospinning
Bone regeneration
Bone filling material
Issue Date: 2020
Publisher: SAGE Publications
Abstract: The aim of this study was to produce three-dimensional, nanofibrous fish scale/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) composite scaffolds as bone filling materials. This is the first report wherein fish scales were used within a nanofibrous matrix for bone regeneration. Composite scaffolds with a cotton wool-like structure (fiber diameter: 560 +/- 64 nm; porosity: 82%) were obtained by incorporating chopped fish scales into wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanofibers and freeze-drying. The addition of the fish scales improved the mechanical properties, biomineralization tendency, cell viability, alkaline phosphatase activity, and type I collagen production. Consequently, produced composite scaffolds would be regarded to have the therapeutic capacity in bone tissue damages.
URI: https://doi.org/10.1177/0885328220901987
https://hdl.handle.net/11147/8881
ISSN: 0885-3282
1530-8022
Appears in Collections:Bioengineering / Biyomühendislik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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