Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/8925
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dc.contributor.authorTürker, Esra-
dc.contributor.authorYıldız, Ümit Hakan-
dc.contributor.authorArslan Yıldız, Ahu-
dc.date.accessioned2020-07-18T08:34:08Z-
dc.date.available2020-07-18T08:34:08Z-
dc.date.issued2019-
dc.identifier.issn0141-8130-
dc.identifier.issn1879-0003-
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2019.08.082-
dc.identifier.urihttps://hdl.handle.net/11147/8925-
dc.descriptionPubMed: 31404597en_US
dc.description.abstractElectrospun collagen is commonly used as a scaffold in tissue engineering applications since it mimics the content and morphology of native extracellular matrix (ECM) well. This report describes "toxic solvent free" fabrication of electrospun hybrid scaffold consisting of Collagen (Col) and Poly(L-lactide-co-epsilon-caprolactone) (PLLCL) for three-dimensional (3D) cell culture. Biomimetic hybrid scaffold was fabricated via co-spinning approach where simultaneous electrospinning of PLLCL and Collagen was mediated by polymer sacrificing agent Polyvinylpyrrolidone (PVP). Acidified aqueous solution of PVP was used to solubilize collagen without using toxic solvents for electrospinning, and then PVP was readily removed by rinsing in water. Mechanical characterizations, protein adsorption, as well as biodegradation analysis have been conducted to investigate feasibility of biomimetic hybrid scaffold for 3D cell culture applications. Electrospun biomimetic hybrid scaffold, which has 3D-network structure with 300-450 nm fiber diameters, was found to be maximizing cell adhesion through assisting NIH 3T3 mouse fibroblast cells. 3D cell culture studies confirmed that presence of collagen in biomimetic hybrid scaffold have created a major impact on cell proliferation compared to conventional 2D systems on long-term, also cell viability increased with the increasing amount of collagen. (c) 2019 Elsevier B.V. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofInternational Journal of Biological Macromoleculesen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCollagenen_US
dc.subjectBiomimetic scaffolden_US
dc.subjectCo-electrospinningen_US
dc.subject3D cell cultureen_US
dc.subjectTissue engineeringen_US
dc.titleBiomimetic hybrid scaffold consisting of co-electrospun collagen and PLLCL for 3D cell cultureen_US
dc.typeArticleen_US
dc.institutionauthorTürker, Esra-
dc.institutionauthorYıldız, Umit Hakan-
dc.institutionauthorArslan Yıldız, Ahu-
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.departmentİzmir Institute of Technology. Chemistryen_US
dc.identifier.volume139en_US
dc.identifier.startpage1054en_US
dc.identifier.endpage1062en_US
dc.identifier.wosWOS:000506421200108en_US
dc.identifier.scopus2-s2.0-85070572451en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.ijbiomac.2019.08.082-
dc.identifier.pmid31404597en_US
dc.relation.doi10.1016/j.ijbiomac.2019.08.082en_US
dc.coverage.doi10.1016/j.ijbiomac.2019.08.082en_US
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept01.01. Units Affiliated to the Rectorate-
crisitem.author.dept04.01. Department of Chemistry-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
Chemistry / Kimya
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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